AMT hydrochloride

Cat. No.: HY-101251 Purity: 99.03%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

AMT hydrochloride is a selective inhibitor of inducible NOS (iNOS) with K_i of 4.2 nM.

For research use only. We do not sell to patients.

AMT hydrochloride Chemical Structure

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10 mg		Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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nNOS iNOS eNOS

Biological Activity
Purity & Documentation
References
Customer Review

Description

AMT hydrochloride is a selective inhibitor of inducible NOS (iNOS) with K_i of 4.2 nM^[1].

IC₅₀ & Target

iNOS

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	0.022 μM Compound: AMT	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reaction Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reaction	[PMID: 21050759]
RAW264.7	IC₅₀	0.022 μM Compound: AMT	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by Griess reaction method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by Griess reaction method	[PMID: 23357630]

Clinical Trial

Molecular Weight

166.67

Formula

C₅H₁₁ClN₂S

CAS No.

21463-31-0

Appearance

Solid

Color

White to off-white

SMILES

NC1=NCCC(C)S1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 16 mg/mL (96.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.9999 mL	29.9994 mL	59.9988 mL
5 mM	1.2000 mL	5.9999 mL	11.9998 mL
10 mM	0.6000 mL	2.9999 mL	5.9999 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.03%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (247 KB) HNMR (238 KB) RP-HPLC (139 KB)

Handling Instructions (2659 KB)

References

[1]. Nakane M, Klinghofer V, Kuk JE, et al. Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol Pharmacol. 1995;47(4):831-834. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.9999 mL	29.9994 mL	59.9988 mL	149.9970 mL
	5 mM	1.2000 mL	5.9999 mL	11.9998 mL	29.9994 mL
	10 mM	0.6000 mL	2.9999 mL	5.9999 mL	14.9997 mL
	15 mM	0.4000 mL	2.0000 mL	3.9999 mL	9.9998 mL
	20 mM	0.3000 mL	1.5000 mL	2.9999 mL	7.4999 mL
	25 mM	0.2400 mL	1.2000 mL	2.4000 mL	5.9999 mL
	30 mM	0.2000 mL	1.0000 mL	2.0000 mL	4.9999 mL
	40 mM	0.1500 mL	0.7500 mL	1.5000 mL	3.7499 mL
	50 mM	0.1200 mL	0.6000 mL	1.2000 mL	2.9999 mL
	60 mM	0.1000 mL	0.5000 mL	1.0000 mL	2.5000 mL
	80 mM	0.0750 mL	0.3750 mL	0.7500 mL	1.8750 mL