Angelicain (Synonyms: Norcimifugin)

Name: Angelicain
Brand: MedChemExpress
SKU: HY-N6941
Rating: 4.5 (1 reviews)

Cat. No.: HY-N6941 Purity: 99.91%: FAQs
Data Sheet SDS COA Handling Instructions

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Angelicain (Norcimifugin) is a constituent of Cimicifuga foetida with anti-inflammatory activity.

For research use only. We do not sell to patients.

Angelicain Chemical Structure

CAS No. : 49624-66-0

Size	Price	Stock	Quantity
1 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Angelicain (Norcimifugin) is a constituent of Cimicifuga foetida with anti-inflammatory activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	5.55 μM Compound: 15	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 20121210]
HT-29	IC₅₀	> 100 μM Compound: 15	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 20121210]
MCF7	IC₅₀	> 100 μM Compound: 15	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 20121210]
MKN-28	IC₅₀	> 100 μM Compound: 15	Cytotoxicity against human MKN28 cells after 72 hrs by MTT assay Cytotoxicity against human MKN28 cells after 72 hrs by MTT assay	[PMID: 20121210]

Molecular Weight

292.28

Formula

C₁₅H₁₆O₆

CAS No.

49624-66-0

Appearance

Solid

Color

White to off-white

SMILES

O=C1C=C(CO)OC2=CC(O[C@H](C(C)(O)C)C3)=C3C(O)=C12

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (342.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4214 mL	17.1069 mL	34.2138 mL
5 mM	0.6843 mL	3.4214 mL	6.8428 mL
10 mM	0.3421 mL	1.7107 mL	3.4214 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.91%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (246 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Lu L, et al. Studies on the constituents of Cimicifuga foetida collected in Guizhou Province and their cytotoxic activities. Chem Pharm Bull (Tokyo). 2012;60(5):571-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4214 mL	17.1069 mL	34.2138 mL	85.5344 mL
	5 mM	0.6843 mL	3.4214 mL	6.8428 mL	17.1069 mL
	10 mM	0.3421 mL	1.7107 mL	3.4214 mL	8.5534 mL
	15 mM	0.2281 mL	1.1405 mL	2.2809 mL	5.7023 mL
	20 mM	0.1711 mL	0.8553 mL	1.7107 mL	4.2767 mL
	25 mM	0.1369 mL	0.6843 mL	1.3686 mL	3.4214 mL
	30 mM	0.1140 mL	0.5702 mL	1.1405 mL	2.8511 mL
	40 mM	0.0855 mL	0.4277 mL	0.8553 mL	2.1384 mL
	50 mM	0.0684 mL	0.3421 mL	0.6843 mL	1.7107 mL
	60 mM	0.0570 mL	0.2851 mL	0.5702 mL	1.4256 mL
	80 mM	0.0428 mL	0.2138 mL	0.4277 mL	1.0692 mL
	100 mM	0.0342 mL	0.1711 mL	0.3421 mL	0.8553 mL

Angelicain Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Angelicain49624-66-0NorcimifuginOthersInhibitorinhibitorinhibit

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Angelicain (Synonyms: Norcimifugin)

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Complete Stock Solution Preparation Table

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