2. Apoptosis
  3. Apoptosis
  4. ar-Turmerone

ar-Turmerone  (Synonyms: (+)-ar-Turmerone)

Cat. No.: HY-N6703 Purity: 98.52%
SDS COA Handling Instructions

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ar-Turmerone ((+)-ar-Turmerone) is a major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone activates apoptotic protein in human lymphoma U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation and constitutes a promising therapeutic agent for various neurologic disorders.

For research use only. We do not sell to patients.

ar-Turmerone Chemical Structure

ar-Turmerone Chemical Structure

CAS No. : 532-65-0

Size Price Stock Quantity
5 mg USD 260 In-stock
10 mg USD 450 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of ar-Turmerone:

ar-Turmerone Related Antibodies

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Description

ar-Turmerone ((+)-ar-Turmerone) is a major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities[1][2][3]. ar-Turmerone activates apoptotic protein in human lymphoma U937 cells[3]. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation and constitutes a promising therapeutic agent for various neurologic disorders[4][5].

Molecular Weight

216.32

Formula

C15H20O
CAS No.
Appearance

Liquid (Density: 0.945 g/cm3)

Color

Colorless to light yellow

SMILES

CC1=CC=C(C=C1)[C@H](CC(/C=C(C)\C)=O)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 50 mg/mL (231.14 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6228 mL 23.1139 mL 46.2278 mL
5 mM 0.9246 mL 4.6228 mL 9.2456 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 0.62 mg/mL (2.87 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.62 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (6.2 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% EtOH    90% Corn Oil

    Solubility: ≥ 0.62 mg/mL (2.87 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.62 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (6.2 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.52%

SDS (537 KB)

COA (244 KB) RP-HPLC (418 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 4.6228 mL 23.1139 mL 46.2278 mL 115.5695 mL
5 mM 0.9246 mL 4.6228 mL 9.2456 mL 23.1139 mL
10 mM 0.4623 mL 2.3114 mL 4.6228 mL 11.5570 mL
15 mM 0.3082 mL 1.5409 mL 3.0819 mL 7.7046 mL
20 mM 0.2311 mL 1.1557 mL 2.3114 mL 5.7785 mL
25 mM 0.1849 mL 0.9246 mL 1.8491 mL 4.6228 mL
30 mM 0.1541 mL 0.7705 mL 1.5409 mL 3.8523 mL
40 mM 0.1156 mL 0.5778 mL 1.1557 mL 2.8892 mL
50 mM 0.0925 mL 0.4623 mL 0.9246 mL 2.3114 mL
60 mM 0.0770 mL 0.3852 mL 0.7705 mL 1.9262 mL
80 mM 0.0578 mL 0.2889 mL 0.5778 mL 1.4446 mL
100 mM 0.0462 mL 0.2311 mL 0.4623 mL 1.1557 mL
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ar-Turmerone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ar-Turmerone532-65-0(+)-ar-TurmeroneApoptosisInhibitorinhibitorinhibit

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