2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor 5-HT Receptor
  4. ARC 239

ARC 239 is an α2B/C-adrenergic receptor antagonist with pKi of 7.06 and 6.95 for rat kidney α2B and human α2C, respectively. ARC 239 also inhibits 5-HT1A receptor with a Ki of 63.1 nM.

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ARC 239 Chemical Structure

ARC 239 Chemical Structure

CAS No. : 67339-62-2

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5 mg USD 95 In-stock
10 mg USD 165 In-stock
25 mg USD 345 In-stock
50 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of ARC 239:

ARC 239 Related Antibodies

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α adrenergic receptor β adrenergic receptor

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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Description

ARC 239 is an α2B/C-adrenergic receptor antagonist with pKi of 7.06 and 6.95 for rat kidney α2B and human α2C, respectively. ARC 239 also inhibits 5-HT1A receptor with a Ki of 63.1 nM[1][2].

IC50 & Target[1][2]

human α2C-adrenoceptor

6.95 (pKi)

Alpha-2C adrenergic receptor

7.06 (pKi)

5-HT1A Receptor

63.1 nM (Ki)

Molecular Weight

407.51

Formula

C24H29N3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CCN2CCN(C3=CC=CC=C3OC)CC2)C(C(C)(C)C4=C1C=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (122.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4539 mL 12.2696 mL 24.5393 mL
5 mM 0.4908 mL 2.4539 mL 4.9079 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4539 mL 12.2696 mL 24.5393 mL 61.3482 mL
5 mM 0.4908 mL 2.4539 mL 4.9079 mL 12.2696 mL
10 mM 0.2454 mL 1.2270 mL 2.4539 mL 6.1348 mL
15 mM 0.1636 mL 0.8180 mL 1.6360 mL 4.0899 mL
20 mM 0.1227 mL 0.6135 mL 1.2270 mL 3.0674 mL
25 mM 0.0982 mL 0.4908 mL 0.9816 mL 2.4539 mL
30 mM 0.0818 mL 0.4090 mL 0.8180 mL 2.0449 mL
40 mM 0.0613 mL 0.3067 mL 0.6135 mL 1.5337 mL
50 mM 0.0491 mL 0.2454 mL 0.4908 mL 1.2270 mL
60 mM 0.0409 mL 0.2045 mL 0.4090 mL 1.0225 mL
80 mM 0.0307 mL 0.1534 mL 0.3067 mL 0.7669 mL
100 mM 0.0245 mL 0.1227 mL 0.2454 mL 0.6135 mL
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ARC 239 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARC 23967339-62-2ARC239ARC-239Adrenergic Receptor5-HT ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine Receptorα2B/C-adrenergic receptor antagonist5-HT1A receptorInhibitorinhibitorinhibit

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