2. Neuronal Signaling
  3. Monoamine Oxidase Cholinesterase (ChE)
  4. ASS234

ASS234 is a potent monoamino oxidase (MAO) inhibitor with IC50s of 5.2 nM and 43 nM for MAO-A and MAO-B, respectively. ASS234 also inhibits AChE and BuChE with IC50s of 350 nM and 460 nM, respectively.

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ASS234 Chemical Structure

ASS234 Chemical Structure

CAS No. : 1334106-34-1

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Based on 1 publication(s) in Google Scholar

ASS234 Related Antibodies

Top Publications Citing Use of Products

View All Monoamine Oxidase Isoform Specific Products:

View All Isoforms
MAO-A MAO-B

View All Cholinesterase (ChE) Isoform Specific Products:

View All Isoforms
AChE BChE

  • Biological Activity

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Description

ASS234 is a potent monoamino oxidase (MAO) inhibitor with IC50s of 5.2 nM and 43 nM for MAO-A and MAO-B, respectively. ASS234 also inhibits AChE and BuChE with IC50s of 350 nM and 460 nM, respectively[1].

IC50 & Target[1]

MAO-A

5.2 nM (IC50)

MAO-B

43 nM (IC50)

AChE

350 nM (IC50)

BChE

460 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
0.38 μM
Compound: 5
Inhibition of cerebral human recombinant AchE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate addition by Ellman's method
Inhibition of cerebral human recombinant AchE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate addition by Ellman's method
[PMID: 22023459]
HEK293 IC50
3.3 μM
Compound: II, ASS234
Inhibition of recombinant human BuChE expressed in HEK293 cells preincubated for 15 mins
Inhibition of recombinant human BuChE expressed in HEK293 cells preincubated for 15 mins
[PMID: 25418133]
HEK293 IC50
3.4 μM
Compound: II, ASS234
Inhibition of recombinant human AChE expressed in HEK293 cells preincubated for 15 mins
Inhibition of recombinant human AChE expressed in HEK293 cells preincubated for 15 mins
[PMID: 25418133]
Molecular Weight

443.62

Formula

C29H37N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C#CCN(C)CC1=CC2=C(C=CC(OCCCC3CCN(CC3)CC4=CC=CC=C4)=C2)N1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.6%

SDS (393 KB)

COA (243 KB)

Handling Instructions (2659 KB)
References
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ASS234 Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASS2341334106-34-1ASS 234ASS-234Monoamine OxidaseCholinesterase (ChE)MAOMAO-AMAO-BAChEBuChEInhibitorinhibitorinhibit

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