2. Immunology/Inflammation
  3. Thrombopoietin Receptor
  4. Avatrombopag maleate

Avatrombopag maleate  (Synonyms: AKR-501 maleate; E5501 maleate; YM477 maleate)

Cat. No.: HY-13463A Purity: 99.88%
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Avatrombopag maleate (AKR-501) is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag maleate mimics the biological activities of TPO. Avatrombopag maleate increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag maleate is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A.

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Avatrombopag maleate Chemical Structure

Avatrombopag maleate Chemical Structure

CAS No. : 677007-74-8

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10 mM * 1 mL in DMSO
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Based on 3 publication(s) in Google Scholar

Other Forms of Avatrombopag maleate:

Avatrombopag maleate Related Antibodies

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Description

Avatrombopag maleate (AKR-501) is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag maleate mimics the biological activities of TPO. Avatrombopag maleate increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag maleate is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A[1][2][3].

Clinical Trial
Molecular Weight

765.73

Formula

C33H38Cl2N6O7S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1CCN(C2=NC=C(C(NC3=NC(C4=CC(Cl)=CS4)=C(N5CCN(C6CCCCC6)CC5)S3)=O)C=C2Cl)CC1)O.O=C(O)/C=C\C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (228.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3059 mL 6.5297 mL 13.0594 mL
5 mM 0.2612 mL 1.3059 mL 2.6119 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3059 mL 6.5297 mL 13.0594 mL 32.6486 mL
5 mM 0.2612 mL 1.3059 mL 2.6119 mL 6.5297 mL
10 mM 0.1306 mL 0.6530 mL 1.3059 mL 3.2649 mL
15 mM 0.0871 mL 0.4353 mL 0.8706 mL 2.1766 mL
20 mM 0.0653 mL 0.3265 mL 0.6530 mL 1.6324 mL
25 mM 0.0522 mL 0.2612 mL 0.5224 mL 1.3059 mL
30 mM 0.0435 mL 0.2177 mL 0.4353 mL 1.0883 mL
40 mM 0.0326 mL 0.1632 mL 0.3265 mL 0.8162 mL
50 mM 0.0261 mL 0.1306 mL 0.2612 mL 0.6530 mL
60 mM 0.0218 mL 0.1088 mL 0.2177 mL 0.5441 mL
80 mM 0.0163 mL 0.0816 mL 0.1632 mL 0.4081 mL
100 mM 0.0131 mL 0.0653 mL 0.1306 mL 0.3265 mL
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Avatrombopag maleate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avatrombopag677007-74-8AKR-501E5501YM477AKR501AKR 501E 5501E-5501YM 477YM-477Thrombopoietin ReceptormimicTPOmegakaryocytopoiesismegakaryocytesphosphorylationproliferationNOD/SCIDInhibitorinhibitorinhibit

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