2. Apoptosis Immunology/Inflammation
  3. Apoptosis NO Synthase COX
  4. Bacoside A3

Bacoside A3 is a triterpenoid saponin isolated from Bacopa monnieri. Bacoside A3 has neuroprotective activity, downregulating β-amyloid-induced inflammatory responses and inhibiting neuronal apoptosis. Bacoside A3 can be used in the study of Alzheimer's disease.

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Bacoside A3 Chemical Structure

Bacoside A3 Chemical Structure

CAS No. : 157408-08-7

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5 mg USD 500 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Bacoside A3:

Bacoside A3 Related Antibodies

Top Publications Citing Use of Products

View All NO Synthase Isoform Specific Products:

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nNOS iNOS eNOS

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COX COX-1 COX-2 COX-3

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  • Purity & Documentation

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Description

Bacoside A3 is a triterpenoid saponin isolated from Bacopa monnieri. Bacoside A3 has neuroprotective activity, downregulating β-amyloid-induced inflammatory responses and inhibiting neuronal apoptosis. Bacoside A3 can be used in the study of Alzheimer's disease[1][2].

In Vitro

Bacoside A3 (0.5-5 μM; 24 h) prevents β-amyloid (10 μM)-mediated growth inhibition of U87MG cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bacoside A3 Related Antibodies

Western Blot Analysis[2]

Cell Line: U87MG cells
Concentration: 0.5, 1, 1.5, 2.5 and 5 μM
Incubation Time: 24 h
Result: Inhibited the formation of iNOS mediated by β-amyloid in U87MG cells in a dose-dependent manner and completely alleviated the effect of β-amyloid on iNOS synthesis at a dose of 5 μM.

RT-PCR[2]

Cell Line: U87MG cells
Concentration: 0.5, 1, 1.5, 2.5 and 5 μM
Incubation Time: 24 h
Result: Inhibited overexpression of COX-2 mRNA, and the inhibition level of COX-2 level in U87MG cells at a dose of 5 μM is close to that of the control group.
Molecular Weight

929.10

Formula

C47H76O18
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@]34[C@@](CC[C@]1([H])[C@@]5([C@@](C(C)([C@@H](O[C@@]6([H])[C@@H]([C@H]([C@H](O)[C@@H](CO)O6)O[C@]7([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)CO)O[C@]8([H])O[C@@H](CO)[C@H](O)[C@H]8O)CC5)C)([H])CC2)C)([H])[C@]9([H])[C@@](OC4)(O[C@@H](/C=C(C)/C)C[C@@]9(O)C)C3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (107.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0763 mL 5.3816 mL 10.7631 mL
5 mM 0.2153 mL 1.0763 mL 2.1526 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation

Purity: 98.47%

COA (257 KB) HNMR (118 KB) RP-HPLC (113 KB) MS (65 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0763 mL 5.3816 mL 10.7631 mL 26.9078 mL
5 mM 0.2153 mL 1.0763 mL 2.1526 mL 5.3816 mL
10 mM 0.1076 mL 0.5382 mL 1.0763 mL 2.6908 mL
15 mM 0.0718 mL 0.3588 mL 0.7175 mL 1.7939 mL
20 mM 0.0538 mL 0.2691 mL 0.5382 mL 1.3454 mL
25 mM 0.0431 mL 0.2153 mL 0.4305 mL 1.0763 mL
30 mM 0.0359 mL 0.1794 mL 0.3588 mL 0.8969 mL
40 mM 0.0269 mL 0.1345 mL 0.2691 mL 0.6727 mL
50 mM 0.0215 mL 0.1076 mL 0.2153 mL 0.5382 mL
60 mM 0.0179 mL 0.0897 mL 0.1794 mL 0.4485 mL
80 mM 0.0135 mL 0.0673 mL 0.1345 mL 0.3363 mL
100 mM 0.0108 mL 0.0538 mL 0.1076 mL 0.2691 mL
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Bacoside A3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bacoside A3157408-08-7Bacoside A 3Bacoside A-3ApoptosisNO SynthaseCOXNitric oxide synthasesNOSCyclooxygenaseInhibitorinhibitorinhibit

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