2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Batabulin sodium

Batabulin sodium  (Synonyms: T138067 sodium)

Cat. No.: HY-13563A Purity: 99.76%
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Batabulin sodium (T138067 sodium) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin sodium affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death.

For research use only. We do not sell to patients.

Batabulin sodium Chemical Structure

Batabulin sodium Chemical Structure

CAS No. : 195533-98-3

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10 mM * 1 mL in DMSO
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10 mg USD 220 In-stock
25 mg USD 380 In-stock
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Based on 1 publication(s) in Google Scholar

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Batabulin sodium Related Antibodies

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Description

Batabulin sodium (T138067 sodium) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin sodium affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death[1].

IC50 & Target

β-tubulin[1]
In Vitro

Batabulin (T138067; 30-300 nM; 24 hours; MCF7 cells) treatment shows approximately 25-30% tetraploid (4n) DNA content in cells, indicating an arrest at the G2/M cell-cycle boundary[1].
Batabulin (T138067; 30-300 nM; 24-48 hours; MCF7 cells) treatment shows 25-30% apoptosis. After a 48-hr exposure to 100 nM Batabulin, approximately 50-80% of the cell population is undergoing apoptosis[1].
Batabulin (T138067) binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Covalent modification occurs at a conserved Cys-239 shared by the β1, β2, and β4 tubulin isotypes. Cells exposed to Batabulin become altered in shape, indicating a collapse of the cytoskeleton, and show an increase in chromosomal ploidy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Batabulin sodium Related Antibodies

Cell Cycle Analysis[1]

Cell Line: MCF7 cells
Concentration: 30 nM, 100 nM and 300 nM
Incubation Time: 24 hours
Result: Showed an arrest at the G2/M cell-cycle boundary.

Apoptosis Analysis[1]

Cell Line: MCF7 cells
Concentration: 30 nM, 100 nM and 300 nM
Incubation Time: 24 hours or 48 hours
Result: 25-30% of cells showed the reduced DNA content characteristic of apoptotic cells.
In Vivo

Batabulin (T138067; 40 mg/kg; intraperitoneal injection; once per week; on days 5, 12, and 19; male athymic nude mice) treatment impairs the growth of the drug-sensitive CCRF-CEM tumors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic nude mice (nu/nu) (6-8 week-old, 20-25 g) injected with CCRF-CEM cells[1]
Dosage: 40 mg/kg
Administration: Intraperitoneal injection; once per week; on days 5, 12, and 19
Result: Impaired the growth of the drug-sensitive CCRF-CEM tumors.
Clinical Trial
Molecular Weight

393.24

Formula

C13H6F6NNaO3S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(C1=C(F)C(F)=C(F)C(F)=C1F)([N-]C2=CC=C(OC)C(F)=C2)=O.[Na+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (317.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5430 mL 12.7149 mL 25.4298 mL
5 mM 0.5086 mL 2.5430 mL 5.0860 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5430 mL 12.7149 mL 25.4298 mL 63.5744 mL
5 mM 0.5086 mL 2.5430 mL 5.0860 mL 12.7149 mL
10 mM 0.2543 mL 1.2715 mL 2.5430 mL 6.3574 mL
15 mM 0.1695 mL 0.8477 mL 1.6953 mL 4.2383 mL
20 mM 0.1271 mL 0.6357 mL 1.2715 mL 3.1787 mL
25 mM 0.1017 mL 0.5086 mL 1.0172 mL 2.5430 mL
30 mM 0.0848 mL 0.4238 mL 0.8477 mL 2.1191 mL
40 mM 0.0636 mL 0.3179 mL 0.6357 mL 1.5894 mL
50 mM 0.0509 mL 0.2543 mL 0.5086 mL 1.2715 mL
60 mM 0.0424 mL 0.2119 mL 0.4238 mL 1.0596 mL
80 mM 0.0318 mL 0.1589 mL 0.3179 mL 0.7947 mL
100 mM 0.0254 mL 0.1271 mL 0.2543 mL 0.6357 mL
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Batabulin sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Batabulin195533-98-3T138067T 138067T-138067Microtubule/TubulinApoptosisAntimitoticβ-tubulinantitumormultidrug-resistantpolymerizationCys-239covalentcytoskeletoncell-cyclearrestInhibitorinhibitorinhibit

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