2. NF-κB Metabolic Enzyme/Protease
  3. Keap1-Nrf2 E1/E2/E3 Enzyme
  4. BC-1901S

BC-1901S is a proteasome-independent NRF2 activator and stabilizer. BC-1901S binds to DCAF1 (E3 ligase subunit) and disrupts NRF2/DCAF1 interaction, and activates NRF2 by inhibiting NRF2 ubiquitination in a KEAP1-independent manner. BC-1901S shows anti-inflammatory effect in a murine model of LPS-induced acute lung injury.

For research use only. We do not sell to patients.

BC-1901S Chemical Structure

BC-1901S Chemical Structure

CAS No. : 1358617-36-3

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BC-1901S Related Antibodies

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Description

BC-1901S is a proteasome-independent NRF2 activator and stabilizer. BC-1901S binds to DCAF1 (E3 ligase subunit) and disrupts NRF2/DCAF1 interaction, and activates NRF2 by inhibiting NRF2 ubiquitination in a KEAP1-independent manner. BC-1901S shows anti-inflammatory effect in a murine model of LPS-induced acute lung injury[1].

Molecular Weight

424.90

Formula

C23H22ClFN4O
CAS No.
SMILES

O=C(C1CCN(CC1)C2=NC(C3=CC(C)=CC=C3)=NC=C2)NC4=CC=C(C(Cl)=C4)F
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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BC-1901S Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BC-1901S1358617-36-3Keap1-Nrf2E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseacute lung injuryanti-inflammatoryDCAF1Inhibitorinhibitorinhibit

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