2. Cell Cycle/DNA Damage
  3. Polo-like Kinase (PLK)
  4. BI2536-PEG2-Halo

BI2536-PEG2-Halo is a bifunctional molecule containing a ligand for Halo tag and a Polo-like kinase 1 (PLK1) inhibitor BI-2536 (HY-50698). BI2536-PEG2-Halo inhibits the proliferation of 293T cells with Halo-p53R273H(FL)-mCherry tag (IC50=23 nM), exhibits selective toxicity against p53 mutant cancer cells.

For research use only. We do not sell to patients.

BI2536-PEG2-Halo Chemical Structure

BI2536-PEG2-Halo Chemical Structure

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BI2536-PEG2-Halo Related Antibodies

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Description

BI2536-PEG2-Halo is a bifunctional molecule containing a ligand for Halo tag and a Polo-like kinase 1 (PLK1) inhibitor BI-2536 (HY-50698). BI2536-PEG2-Halo inhibits the proliferation of 293T cells with Halo-p53R273H(FL)-mCherry tag (IC50=23 nM), exhibits selective toxicity against p53 mutant cancer cells[1].

Molecular Weight

790.39

Formula

C39H60ClN7O8
SMILES

O=C(NCCOCCOCCC(NCCOCCOCCCCCCCl)=O)C1=CC=C(NC(N=C2N(C3CCCC3)[C@@H]4CC)=NC=C2N(C)C4=O)C(OC)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BI2536-PEG2-Halo Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BI2536-PEG2-HaloPolo-like Kinase (PLK)293Tbifunctionalp53 mutantInhibitorinhibitorinhibit

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