2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. BIP-135

BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect.

For research use only. We do not sell to patients.

BIP-135 Chemical Structure

BIP-135 Chemical Structure

CAS No. : 941575-71-9

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Customer Review

Based on 1 publication(s) in Google Scholar

BIP-135 Related Antibodies

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GSK-3 GSK-3α GSK-3β

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Description

BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect[1].

IC50 & Target

GSK-3α

16 nM (IC50)

GSK-3β

21 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HuP-T3 IC50
43 μM
Compound: 13
Growth inhibition of human HUPT3 cells after 72 hrs by MTS assay
Growth inhibition of human HUPT3 cells after 72 hrs by MTS assay
[PMID: 19338355]
MIA PaCa-2 IC50
30 μM
Compound: 13
Growth inhibition of human MIAPaCa2 cells after 72 hrs by MTS assay
Growth inhibition of human MIAPaCa2 cells after 72 hrs by MTS assay
[PMID: 19338355]
In Vitro

BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations[1].
BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BIP-135 Related Antibodies

Western Blot Analysis[1]

Cell Line: Human SMA fibroblasts
Concentration: 20 μM, 25 μM, 30 μM
Incubation Time: 72 hours
Result: Led to a 7-fold increase in SMN levels at 25 μM.
In Vivo

BIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight)[1].
BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female SMN2+/+, SMN2Δ7+/+, Smn+/– mice[1]
Dosage: 75 mg/kg
Administration: Intraperitoneal injection; daily; from postnatal day 0 to 21
Result: Caused a modest extension in the median survival of SMA KO animals by two days.
Molecular Weight

421.24

Formula

C21H13BrN2O3
CAS No.
Appearance

Solid

Color

Light yellow to orange

SMILES

O=C(C(C1=COC2=CC=CC=C12)=C3C4=CN(C)C5=C4C=C(Br)C=C5)NC3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (148.37 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3739 mL 11.8697 mL 23.7394 mL
5 mM 0.4748 mL 2.3739 mL 4.7479 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.86%

SDS (419 KB)

COA (257 KB) HNMR (274 KB) LCMS (271 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3739 mL 11.8697 mL 23.7394 mL 59.3486 mL
5 mM 0.4748 mL 2.3739 mL 4.7479 mL 11.8697 mL
10 mM 0.2374 mL 1.1870 mL 2.3739 mL 5.9349 mL
15 mM 0.1583 mL 0.7913 mL 1.5826 mL 3.9566 mL
20 mM 0.1187 mL 0.5935 mL 1.1870 mL 2.9674 mL
25 mM 0.0950 mL 0.4748 mL 0.9496 mL 2.3739 mL
30 mM 0.0791 mL 0.3957 mL 0.7913 mL 1.9783 mL
40 mM 0.0593 mL 0.2967 mL 0.5935 mL 1.4837 mL
50 mM 0.0475 mL 0.2374 mL 0.4748 mL 1.1870 mL
60 mM 0.0396 mL 0.1978 mL 0.3957 mL 0.9891 mL
80 mM 0.0297 mL 0.1484 mL 0.2967 mL 0.7419 mL
100 mM 0.0237 mL 0.1187 mL 0.2374 mL 0.5935 mL
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BIP-135 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIP-135941575-71-9BIP135BIP 135GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3neuroprotectiveSMNspinalmuscularatrophy,SMAInhibitorinhibitorinhibit

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