Bisdemethoxycucurmin (Synonyms: Curcumin III; Didemethoxycurcumin)

Cat. No.: HY-N0007A Purity: 98.96%: FAQs
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Bisdemethoxycucurmin (Curcumin III), a curcuminoid, has antioxidant and antiinflammatory activities.

For research use only. We do not sell to patients.

Bisdemethoxycucurmin Chemical Structure

CAS No. : 24939-16-0

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 44	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 44	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 135	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 198	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
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Description

Bisdemethoxycucurmin (Curcumin III), a curcuminoid, has antioxidant and antiinflammatory activities^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	> 100 μM Compound: BDC	Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
A549	IC₅₀	38.1 μM Compound: Bisdemethoxycurcumin	Cytotoxicity against human A549 cells after 72 hrs by crystal violet staining based microplate reader analysis Cytotoxicity against human A549 cells after 72 hrs by crystal violet staining based microplate reader analysis	[PMID: 23153397]
Caco-2	IC₅₀	> 100 μM Compound: 1b	Cytotoxicity against human Caco2 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human Caco2 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 27843113]
Caco-2	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of undifferentiated human Caco2 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay Growth inhibition of undifferentiated human Caco2 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay	[PMID: 27521589]
Caco-2	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of differentiated human Caco2 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay Growth inhibition of differentiated human Caco2 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay	[PMID: 27521589]
Caco-2	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of undifferentiated human Caco2 cells measured after 72 hrs by SRB assay Growth inhibition of undifferentiated human Caco2 cells measured after 72 hrs by SRB assay	[PMID: 27521589]
Caco-2	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of differentiated human Caco2 cells measured after 72 hrs by SRB assay Growth inhibition of differentiated human Caco2 cells measured after 72 hrs by SRB assay	[PMID: 27521589]
CHO-K1	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of CHOK1 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay Growth inhibition of CHOK1 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay	[PMID: 27521589]
CHO-K1	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of CHOK1 cells measured after 72 hrs by SRB assay Growth inhibition of CHOK1 cells measured after 72 hrs by SRB assay	[PMID: 27521589]
CHO-K1	IC₅₀	91.4 μM Compound: 1b	Cytotoxicity against CHOK1 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against CHOK1 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 27843113]
DLD-1	IC₅₀	> 40 μM Compound: BDC	Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
EA.hy 926	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of human EAhy926 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay Growth inhibition of human EAhy926 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay	[PMID: 27521589]
EA.hy 926	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of human EAhy926 cells measured after 72 hrs by SRB assay Growth inhibition of human EAhy926 cells measured after 72 hrs by SRB assay	[PMID: 27521589]
EA.hy 926	IC₅₀	54.3 μM Compound: 1b	Cytotoxicity against human EAhy926 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human EAhy926 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 27843113]
EOL1	IC₅₀	22.3 μM Compound: 4	Cytotoxicity against human EOL-1 cells after 48 hrs by MTT assay Cytotoxicity against human EOL-1 cells after 48 hrs by MTT assay	[PMID: 24689857]
HEK293	EC₅₀	200 μM Compound: 3	Cytotoxicity against HEK293 cells after 16 hrs by alamar blue assay Cytotoxicity against HEK293 cells after 16 hrs by alamar blue assay	[PMID: 20004045]
HepG2	IC₅₀	> 100 μM Compound: 1b	Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 27843113]
HepG2	IC₅₀	62.9 μM Compound: Bisdemethoxycurcumin	Cytotoxicity against human HepG2 cells after 72 hrs by crystal violet staining based microplate reader analysis Cytotoxicity against human HepG2 cells after 72 hrs by crystal violet staining based microplate reader analysis	[PMID: 23153397]
HepG2	IC₅₀	75.5 μM Compound: 1c	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26894841]
HT-29	IC₅₀	> 100 μM Compound: 1b	Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 27843113]
HT-29	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of human HT-29 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay Growth inhibition of human HT-29 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay	[PMID: 27521589]
HT-29	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of human HT-29 cells measured after 72 hrs by SRB assay Growth inhibition of human HT-29 cells measured after 72 hrs by SRB assay	[PMID: 27521589]
KB	IC₅₀	21.44 μM Compound: 3	Cytotoxicity against human KB cells assessed as growth inhibition by resazurin microplate assay Cytotoxicity against human KB cells assessed as growth inhibition by resazurin microplate assay	[PMID: 24857542]
KB	CC₅₀	8.5 μM Compound: 11c	Compound concentration required to reduce the exponential growth of KB cells by 50% Compound concentration required to reduce the exponential growth of KB cells by 50%	[PMID: 9767632]
LNCaP	IC₅₀	19.7 μM Compound: 2	Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay	[PMID: 19249204]
MCF7	IC₅₀	24.3 μM Compound: 2	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 19249204]
MCF7	IC₅₀	48.9 μM Compound: BDC	Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
MDA-MB-231	IC₅₀	11 mM Compound: BDMC	Increase in MMP3 level in human MDA-MB-231 cells after 24 hrs by ELISA Increase in MMP3 level in human MDA-MB-231 cells after 24 hrs by ELISA	[PMID: 31336310]
MDA-MB-231	IC₅₀	21.9 μM Compound: 2	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 19249204]
MDA-MB-231	IC₅₀	24 μM Compound: bisdemethoxycurcumin	Inhibition of TGF-beta-induced PTHrP secretion in human MDA-MB-231 cells treated 4 hrs before TGF-beta challenge measured after 24 hrs by radioimmunoassay Inhibition of TGF-beta-induced PTHrP secretion in human MDA-MB-231 cells treated 4 hrs before TGF-beta challenge measured after 24 hrs by radioimmunoassay	[PMID: 23145932]
MDA-MB-231	IC₅₀	38.5 μM Compound: Bisdemethoxycurcumin	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by crystal violet staining based microplate reader analysis Cytotoxicity against human MDA-MB-231 cells after 72 hrs by crystal violet staining based microplate reader analysis	[PMID: 23153397]
MT4	CC₅₀	13 μM Compound: 11c	Compound concentration required to reduce the exponential growth of MT-4 cells by 50% Compound concentration required to reduce the exponential growth of MT-4 cells by 50%	[PMID: 9767632]
PC-12	ED₅₀	2 μg/mL Compound: 5, bisdemethoxycurcumin	Protection against beta-amyloid (25 to 35) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay Protection against beta-amyloid (25 to 35) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay	[PMID: 12350137]
PC-12	ED₅₀	3.5 μg/mL Compound: 5, bisdemethoxycurcumin	Protection against beta-amyloid (1 to 42) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay Protection against beta-amyloid (1 to 42) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay	[PMID: 12350137]
PC-3	IC₅₀	27.3 μM Compound: 2	Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay	[PMID: 19249204]
WRL68	IC₅₀	45.4 μM Compound: BDC	Cytotoxicity against human WRL68 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human WRL68 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]

Molecular Weight

308.33

Formula

C₁₉H₁₆O₄

CAS No.

24939-16-0

Appearance

Solid

Color

Light yellow to orange

SMILES

O=C(CC(/C=C/C1=CC=C(O)C=C1)=O)/C=C/C2=CC=C(O)C=C2

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 66.67 mg/mL (216.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2433 mL	16.2164 mL	32.4328 mL
5 mM	0.6487 mL	3.2433 mL	6.4866 mL
10 mM	0.3243 mL	1.6216 mL	3.2433 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.96%

Select Batch:

Data Sheet (265 KB) SDS (393 KB)

COA (243 KB) HNMR (277 KB) RP-HPLC (262 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. M Kuroyanagi, et al. [Some observation on curcuminoids from Zingiberaceae plants]. Yakugaku Zasshi. 1970 Nov;90(11):1467-70. [Content Brief]

[2]. Toshiya Masuda, et al. Antioxidative and Antiinflammatory Compounds from Tropical Gingers: Isolation, Structure Determination, and Activities of Cassumunins A, B, and C, New Complex Curcuminoids from Zingiber cassumunar. J. Agric. Food Chem. 1994, 42, 9, 1850–1856

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2433 mL	16.2164 mL	32.4328 mL	81.0820 mL
	5 mM	0.6487 mL	3.2433 mL	6.4866 mL	16.2164 mL
	10 mM	0.3243 mL	1.6216 mL	3.2433 mL	8.1082 mL
	15 mM	0.2162 mL	1.0811 mL	2.1622 mL	5.4055 mL
	20 mM	0.1622 mL	0.8108 mL	1.6216 mL	4.0541 mL
	25 mM	0.1297 mL	0.6487 mL	1.2973 mL	3.2433 mL
	30 mM	0.1081 mL	0.5405 mL	1.0811 mL	2.7027 mL
	40 mM	0.0811 mL	0.4054 mL	0.8108 mL	2.0270 mL
	50 mM	0.0649 mL	0.3243 mL	0.6487 mL	1.6216 mL
	60 mM	0.0541 mL	0.2703 mL	0.5405 mL	1.3514 mL
	80 mM	0.0405 mL	0.2027 mL	0.4054 mL	1.0135 mL
	100 mM	0.0324 mL	0.1622 mL	0.3243 mL	0.8108 mL

Bisdemethoxycucurmin Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bisdemethoxycucurmin24939-16-0Curcumin III DidemethoxycurcuminOtherscurcuminoidantioxidantantiinflammatoryInhibitorinhibitorinhibit

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Bisdemethoxycucurmin (Synonyms: Curcumin III; Didemethoxycurcumin)

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Other Forms of Bisdemethoxycucurmin:

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References

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Complete Stock Solution Preparation Table

Bisdemethoxycucurmin Related Classifications

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