Bleximenib oxalate (Synonyms: Menin-MLL inhibitor 24 oxalate)

Name: Bleximenib oxalate
Brand: MedChemExpress
SKU: HY-148669A
Rating: 4.5 (1 reviews)

Cat. No.: HY-148669A Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Menin-MLL inhibitor 24 (compound A) oxalate is a menin-mixed-lineage leukemia 1 (menin-MLL) inhibitor, and can be used for the research of cancer.

For research use only. We do not sell to patients.

Bleximenib oxalate Chemical Structure

CAS No. : 2866179-95-3

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 1093	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 1093	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 720	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1770	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 3100	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 4470	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Bleximenib oxalate:

(S)-Bleximenib oxalate Get quote
Bleximenib Get quote

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Description

Menin-MLL inhibitor 24 (compound A) oxalate is a menin-mixed-lineage leukemia 1 (menin-MLL) inhibitor, and can be used for the research of cancer^[1].

Molecular Weight

689.82

Formula

C₃₄H₅₂FN₇O₇

CAS No.

2866179-95-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)C(O)=O.COCCN(C)CCC[C@@H](N1CC2(C1)CN(C3=NC=NN=C3OC4=C(C=C(C=C4)F)C(N(CC)C(C)C)=O)CC2)C(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (144.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4497 mL	7.2483 mL	14.4965 mL
5 mM	0.2899 mL	1.4497 mL	2.8993 mL
10 mM	0.1450 mL	0.7248 mL	1.4497 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (253 KB) HNMR (123 KB)

Handling Instructions (2659 KB)

References

[1]. DASKALAKIS N, et, al. Combination therapies. WO2022237720A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4497 mL	7.2483 mL	14.4965 mL	36.2413 mL
	5 mM	0.2899 mL	1.4497 mL	2.8993 mL	7.2483 mL
	10 mM	0.1450 mL	0.7248 mL	1.4497 mL	3.6241 mL
	15 mM	0.0966 mL	0.4832 mL	0.9664 mL	2.4161 mL
	20 mM	0.0725 mL	0.3624 mL	0.7248 mL	1.8121 mL
	25 mM	0.0580 mL	0.2899 mL	0.5799 mL	1.4497 mL
	30 mM	0.0483 mL	0.2416 mL	0.4832 mL	1.2080 mL
	40 mM	0.0362 mL	0.1812 mL	0.3624 mL	0.9060 mL
	50 mM	0.0290 mL	0.1450 mL	0.2899 mL	0.7248 mL
	60 mM	0.0242 mL	0.1208 mL	0.2416 mL	0.6040 mL
	80 mM	0.0181 mL	0.0906 mL	0.1812 mL	0.4530 mL
	100 mM	0.0145 mL	0.0725 mL	0.1450 mL	0.3624 mL

Bleximenib oxalate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bleximenib2866179-95-3Menin-MLL inhibitor 24Epigenetic Reader DomainCancerleukemiaMeninMLLInhibitorinhibitorinhibit

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Bleximenib oxalate (Synonyms: Menin-MLL inhibitor 24 oxalate)

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Other Forms of Bleximenib oxalate:

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References

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Complete Stock Solution Preparation Table

Bleximenib oxalate Related Classifications

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