2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. BLK-IN-2

BLK-IN-2 (compound 25) is a potent and selective irreversible inhibitor of B-Lymphoid tyrosine kinase (BLK), with an IC50 of 5.9 nM. BLK-IN-2 also inhibits BTK (IC50=202.0 nM). BLK-IN-2 shows potent antiproliferative activities against several lymphoma cells.

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BLK-IN-2 Chemical Structure

BLK-IN-2 Chemical Structure

CAS No. : 2694871-86-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 752 In-stock
Solution
10 mM * 1 mL in DMSO USD 752 In-stock
Solid
1 mg USD 200 In-stock
5 mg USD 500 In-stock
10 mg USD 850 In-stock
25 mg USD 1800 In-stock
50 mg USD 3000 In-stock
100 mg USD 4600 In-stock
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Based on 1 publication(s) in Google Scholar

BLK-IN-2 Related Antibodies

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Description

BLK-IN-2 (compound 25) is a potent and selective irreversible inhibitor of B-Lymphoid tyrosine kinase (BLK), with an IC50 of 5.9 nM. BLK-IN-2 also inhibits BTK (IC50=202.0 nM). BLK-IN-2 shows potent antiproliferative activities against several lymphoma cells[1].

IC50 & Target

IC50: 5.9 nM (BLK)[1], 202.0 nM (BTK)[1]
Molecular Weight

683.80

Formula

C39H41N9O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC2=C(C=NC=C2)C=C1)NC3=CC=C(C)C(C(NC4=CN=C(NC5=CC=CC(NC6CCN(C(/C=C/CN(C)C)=O)CC6)=C5)N=C4)=O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (182.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4624 mL 7.3121 mL 14.6242 mL
5 mM 0.2925 mL 1.4624 mL 2.9248 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.72%

COA (243 KB) HNMR (327 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4624 mL 7.3121 mL 14.6242 mL 36.5604 mL
5 mM 0.2925 mL 1.4624 mL 2.9248 mL 7.3121 mL
10 mM 0.1462 mL 0.7312 mL 1.4624 mL 3.6560 mL
15 mM 0.0975 mL 0.4875 mL 0.9749 mL 2.4374 mL
20 mM 0.0731 mL 0.3656 mL 0.7312 mL 1.8280 mL
25 mM 0.0585 mL 0.2925 mL 0.5850 mL 1.4624 mL
30 mM 0.0487 mL 0.2437 mL 0.4875 mL 1.2187 mL
40 mM 0.0366 mL 0.1828 mL 0.3656 mL 0.9140 mL
50 mM 0.0292 mL 0.1462 mL 0.2925 mL 0.7312 mL
60 mM 0.0244 mL 0.1219 mL 0.2437 mL 0.6093 mL
80 mM 0.0183 mL 0.0914 mL 0.1828 mL 0.4570 mL
100 mM 0.0146 mL 0.0731 mL 0.1462 mL 0.3656 mL
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BLK-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BLK-IN-22694871-86-6BtkBruton tyrosine kinaseB-Lymphoid tyrosine kinaseBLKBTKlymphomaInhibitorinhibitorinhibit

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