BTK-IN-29

Cat. No.: HY-160141 Purity: 97.19%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

BTK-IN-29 (compound 14) is an inhibitor of Btk.

For research use only. We do not sell to patients.

BTK-IN-29 Chemical Structure

CAS No. : 2736508-60-2

Size	Price	Stock	Quantity
1 mg	USD 390	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 940	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 3000	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Description

BTK-IN-29 (compound 14) is an inhibitor of Btk^[1].

Molecular Weight

851.01

Formula

C₄₇H₅₄N₁₂O₄

CAS No.

2736508-60-2

Appearance

Solid

Color

Light yellow to green yellow

SMILES

CC1=C([C@@H](C)NC(C2=NC(C(C)(C)C)=NO2)=O)C=CC(C3=C4C(NC(C5=CN=C(N6CCN(CC6)CC7CCN(C8=CC=C(N9C(NC(CC9)=O)=O)C=C8)CC7)C=C5)=C4)=NC=N3)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (146.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1751 mL	5.8754 mL	11.7507 mL
5 mM	0.2350 mL	1.1751 mL	2.3501 mL
10 mM	0.1175 mL	0.5875 mL	1.1751 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.19%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (250 KB) HNMR (310 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Hexiang Wang, et al. Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use. WO2021219070A1. 2021-11-04.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1751 mL	5.8754 mL	11.7507 mL	29.3769 mL
	5 mM	0.2350 mL	1.1751 mL	2.3501 mL	5.8754 mL
	10 mM	0.1175 mL	0.5875 mL	1.1751 mL	2.9377 mL
	15 mM	0.0783 mL	0.3917 mL	0.7834 mL	1.9585 mL
	20 mM	0.0588 mL	0.2938 mL	0.5875 mL	1.4688 mL
	25 mM	0.0470 mL	0.2350 mL	0.4700 mL	1.1751 mL
	30 mM	0.0392 mL	0.1958 mL	0.3917 mL	0.9792 mL
	40 mM	0.0294 mL	0.1469 mL	0.2938 mL	0.7344 mL
	50 mM	0.0235 mL	0.1175 mL	0.2350 mL	0.5875 mL
	60 mM	0.0196 mL	0.0979 mL	0.1958 mL	0.4896 mL
	80 mM	0.0147 mL	0.0734 mL	0.1469 mL	0.3672 mL
	100 mM	0.0118 mL	0.0588 mL	0.1175 mL	0.2938 mL

BTK-IN-29 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BTK-IN-292736508-60-2BtkBruton tyrosine kinasebruton's tyrosine kinaseInhibitorinhibitorinhibit

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