2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. BTK-IN-8

BTK-IN-8 is a potent and selective peripheral covalent BTK inhibitor (IC50=0.22 nM; Kd=0.91 nM). BTK-IN-8 has good whole blood CD69 cellular potency (IC50=0.029 µM).

For research use only. We do not sell to patients.

BTK-IN-8 Chemical Structure

BTK-IN-8 Chemical Structure

CAS No. : 2824922-28-1

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BTK-IN-8 Related Antibodies

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Description

BTK-IN-8 is a potent and selective peripheral covalent BTK inhibitor (IC50=0.22 nM; Kd=0.91 nM). BTK-IN-8 has good whole blood CD69 cellular potency (IC50=0.029 µM)[1].

IC50 & Target

IC50: 0.22 nM (BTK)[1]
In Vitro

BTK-IN-8 (compound 42) shows potent target occupancy in Ramos cells (IC50=3.1 nM) and inhibits BTK-dependent TMD8 cells proliferation (IC50= 1.6 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BTK-IN-8 Related Antibodies
Molecular Weight

480.60

Formula

C26H36N6O3
CAS No.
SMILES

CC(C)CN(CC1=O)CCN1CC(C(C)=C2)=CC=C2C(N=CN=C3N)=C3OCCN(C)C(C=C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BTK-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BTK-IN-82824922-28-1BtkBruton tyrosine kinaseB cellsRamos cellsTMD8 cellspiperazinoneselectivitycells proliferationperipheralcovalentInhibitorinhibitorinhibit

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