2. Metabolic Enzyme/Protease
  3. Acyltransferase
  4. GOAT-IN-1

GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, metabolic, non-alcoholic fatty liver, steatohepatitis, sarcopenia, appetite control, alcohol/narcotic dependence, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral apoplexy, cerebral infarction, cardic disease, some kind of tumors.

For research use only. We do not sell to patients.

GOAT-IN-1 Chemical Structure

GOAT-IN-1 Chemical Structure

CAS No. : 1452473-54-9

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5 mg USD 610 In-stock
10 mg USD 950 In-stock
25 mg USD 1900 In-stock
50 mg USD 3050 In-stock
100 mg USD 4800 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

GOAT-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All Acyltransferase Isoform Specific Products:

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ACAT1 ACAT2 MGAT2 ACAT

  • Biological Activity

  • Purity & Documentation

  • References

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Description

GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, metabolic, non-alcoholic fatty liver, steatohepatitis, sarcopenia, appetite control, alcohol/narcotic dependence, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral apoplexy, cerebral infarction, cardic disease, some kind of tumors.

In Vitro

The inhibitory activity of GOAT-IN-1 (Example 16) for human GOAT is 101% with the concentration of 10 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GOAT-IN-1 Related Antibodies
Molecular Weight

415.81

Formula

C18H13ClF3NO3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=NC(C(F)(F)F)=CC=C1COC2=CC(SC=C3CC(O)=O)=C3C(Cl)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (360.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4049 mL 12.0247 mL 24.0494 mL
5 mM 0.4810 mL 2.4049 mL 4.8099 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4049 mL 12.0247 mL 24.0494 mL 60.1236 mL
5 mM 0.4810 mL 2.4049 mL 4.8099 mL 12.0247 mL
10 mM 0.2405 mL 1.2025 mL 2.4049 mL 6.0124 mL
15 mM 0.1603 mL 0.8016 mL 1.6033 mL 4.0082 mL
20 mM 0.1202 mL 0.6012 mL 1.2025 mL 3.0062 mL
25 mM 0.0962 mL 0.4810 mL 0.9620 mL 2.4049 mL
30 mM 0.0802 mL 0.4008 mL 0.8016 mL 2.0041 mL
40 mM 0.0601 mL 0.3006 mL 0.6012 mL 1.5031 mL
50 mM 0.0481 mL 0.2405 mL 0.4810 mL 1.2025 mL
60 mM 0.0401 mL 0.2004 mL 0.4008 mL 1.0021 mL
80 mM 0.0301 mL 0.1503 mL 0.3006 mL 0.7515 mL
100 mM 0.0240 mL 0.1202 mL 0.2405 mL 0.6012 mL
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GOAT-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GOAT-IN-11452473-54-9AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseInhibitorinhibitorinhibit

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HY-103479
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