BuChE-IN-6

Cat. No.: HY-146251: FAQs
Data Sheet Handling Instructions

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BuChE-IN-6 (compound 1b) is a potent and selective BuChE (butyrylcholinesterase) inhibitor, with IC₅₀ values of 0.46 and 0.51 μM for eqBuChE and hBuChE, respectively. BuChE-IN-6 also inhibits Aβ₄₂ self-aggregation.

For research use only. We do not sell to patients.

BuChE-IN-6 Chemical Structure

CAS No. : 2003213-07-6

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AChE BChE

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	53.8 μM Compound: 1b	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36092141]
HEK293	IC₅₀	23.1 μM Compound: 1b	Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36092141]
MCF-10A	IC₅₀	1.08 μM Compound: 1b	Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36092141]
MCF7	IC₅₀	1.34 μM Compound: 1b	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36092141]
MDA-MB-231	IC₅₀	1.79 μM Compound: 1b	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36092141]
SW480	IC₅₀	8.9 μM Compound: 1b	Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36092141]

Molecular Weight

366.46

Formula

C₂₁H₂₆N₄O₂

CAS No.

2003213-07-6

SMILES

O=C1N(CC2=CN([C@@H]3[C@H](C(C)C)CC[C@@H](C)C3)N=N2)C4=C(C=CC=C4)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Marques CS, et al. N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study. Bioorg Chem. 2020 May;98:103753. [Content Brief]

BuChE-IN-6 Related Classifications

Neurological Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BuChE-IN-62003213-07-6Cholinesterase (ChE)Amyloid-ββ-amyloid peptideAβAbetaIsatinOxindole1,2,3-triazoleButyrylcholinesteraseβ-amyloid inhibitionHepatotoxicityNeurotoxicityInhibitorinhibitorinhibit

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