Budiodarone tartrate (Synonyms: ATI-2042 tartrate)

Name: Budiodarone tartrate
Brand: MedChemExpress
SKU: HY-14834A
Rating: 4.5 (1 reviews)

Cat. No.: HY-14834A Purity: 99.31%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Budiodarone (ATI-2042) tartrate is a chemical analogue of Amiodarone (HY-14187) with balanced, multiple cardiac ion channel (potassium, sodium and calcium channels) inhibiting activity. Budiodarone tartrate is an antiarrhythmic agent.

For research use only. We do not sell to patients.

Budiodarone tartrate Chemical Structure

CAS No. : 478941-93-4

Size	Price	Stock	Quantity
5 mg	USD 510	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 820	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1680	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2680	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 4300	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Budiodarone tartrate:

Budiodarone Get quote

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View All Sodium Channel Isoform Specific Products:

View All Isoforms

Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8

View All Calcium Channel Isoform Specific Products:

View All Isoforms

N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Budiodarone (ATI-2042) tartrate has a short plasma half-life (7 h) and a lower volume of distribution (13 L/kg)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

853.43

Formula

C₃₁H₃₇I₂NO₁₁

CAS No.

478941-93-4

Appearance

Solid

Color

White to yellow

SMILES

O=C(O[C@H](CC)C)CC1=C(C(C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)=O)C3=CC=CC=C3O1.OC([C@H](O)[C@@H](O)C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (117.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1717 mL	5.8587 mL	11.7174 mL
5 mM	0.2343 mL	1.1717 mL	2.3435 mL
10 mM	0.1172 mL	0.5859 mL	1.1717 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1 mg/mL (1.17 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1 mg/mL (1.17 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1 mg/mL (1.17 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.31%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (257 KB) HNMR (272 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Ezekowitz MD, et al. A randomized trial of budiodarone in paroxysmal atrial fibrillation. J Interv Card Electrophysiol. 2012 Jun;34(1):1-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1717 mL	5.8587 mL	11.7174 mL	29.2936 mL
	5 mM	0.2343 mL	1.1717 mL	2.3435 mL	5.8587 mL
	10 mM	0.1172 mL	0.5859 mL	1.1717 mL	2.9294 mL
	15 mM	0.0781 mL	0.3906 mL	0.7812 mL	1.9529 mL
	20 mM	0.0586 mL	0.2929 mL	0.5859 mL	1.4647 mL
	25 mM	0.0469 mL	0.2343 mL	0.4687 mL	1.1717 mL
	30 mM	0.0391 mL	0.1953 mL	0.3906 mL	0.9765 mL
	40 mM	0.0293 mL	0.1465 mL	0.2929 mL	0.7323 mL
	50 mM	0.0234 mL	0.1172 mL	0.2343 mL	0.5859 mL
	60 mM	0.0195 mL	0.0976 mL	0.1953 mL	0.4882 mL
	80 mM	0.0146 mL	0.0732 mL	0.1465 mL	0.3662 mL
	100 mM	0.0117 mL	0.0586 mL	0.1172 mL	0.2929 mL

Budiodarone tartrate Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Budiodarone478941-93-4ATI-2042ATI2042ATI 2042Potassium ChannelSodium ChannelCalcium ChannelKcsANa channelsNa+ channelsCa2+ channelsCa channelsInhibitorinhibitorinhibit

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Budiodarone tartrate (Synonyms: ATI-2042 tartrate)

Customer Review

Other Forms of Budiodarone tartrate:

Budiodarone tartrate Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Sodium Channel Isoform Specific Products:

View All Calcium Channel Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Budiodarone tartrate Related Antibodies

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Complete Stock Solution Preparation Table

Budiodarone tartrate Related Classifications

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