C-11

Cat. No.: HY-100861: FAQs
Data Sheet Handling Instructions

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C-11 is a tubulin inhibitor and acts as an ADC cytotoxin, displays cytotoxicity for carcinoma cell lines.

For research use only. We do not sell to patients.

C-11 Chemical Structure

CAS No. : 2007965-97-9

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Biological Activity
Purity & Documentation
References
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Description

C-11 is a tubulin inhibitor and acts as an ADC cytotoxin, displays cytotoxicity for carcinoma cell lines^[1].

IC₅₀ & Target

Traditional Cytotoxic Agents

Cellular Effect

Cell Line	Type	Value	Description	References
KB	IC₅₀	0.5 nM Compound: 11	Cytotoxicity against MDR1 deficient human KB cells assessed as decrease in cell viability after 4 days by MTS assay Cytotoxicity against MDR1 deficient human KB cells assessed as decrease in cell viability after 4 days by MTS assay	[PMID: 27882198]
MDA-MB-361	IC₅₀	0.9 nM Compound: 11	Cytotoxicity against human MDA-MB-361/DYT2 cells assessed as decrease in cell viability after 4 days by MTS assay Cytotoxicity against human MDA-MB-361/DYT2 cells assessed as decrease in cell viability after 4 days by MTS assay	[PMID: 27882198]
NCI-N87	IC₅₀	1.11 nM Compound: 11	Cytotoxicity against human NCI-N87 cells assessed as decrease in cell viability after 4 days by MTS assay Cytotoxicity against human NCI-N87 cells assessed as decrease in cell viability after 4 days by MTS assay	[PMID: 27882198]

In Vitro

C-11 exhibits cytotoxicity for N87 cells and MDA-MB-361-DYT2 cells with IC₅₀s of 1.11 nM and 0.9 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

742.97

Formula

C₃₈H₅₈N₆O₇S

CAS No.

2007965-97-9

SMILES

O=C(N(C)[C@@H](C(C)C)C[C@@H](OC(C)=O)C1=NC(C(N[C@@H](CC2=CC=C(N)C=C2)C[C@H](C)C(O)=O)=O)=CS1)[C@H]([C@@H](C)CC)NC([C@@]3(C)CCCN3C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Leverett CA, et al. Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads. ACS Med Chem Lett. 2016 Aug 26;7(11):999-1004. [Content Brief]

C-11 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C-112007965-97-9C11C 11ADC CytotoxinMicrotubule/TubulinADC PayloadInhibitorinhibitorinhibit

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