2. PI3K/Akt/mTOR Apoptosis
  3. Akt mTOR Caspase
  4. C-Reactive Protein (CRP) (174-185)

C-Reactive Protein (CRP) (174-185) 

Cat. No.: HY-P1823 Purity: 99.83%
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C-Reactive Protein (CRP) is an anti-pneumococcal plasma protein that can serve as an inflammatory marker. C-Reactive protein can protect mice from pneumococcal infection by activating complement. C-Reactive protein can inhibit the activation of caspase-3/9 through the CD64/AKT/mTOR pathway, thereby promoting chemotherapy resistance in mice with tongue squamous cell carcinoma.

For research use only. We do not sell to patients.

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C-Reactive Protein (CRP) (174-185) Chemical Structure

C-Reactive Protein (CRP) (174-185) Chemical Structure

CAS No. : 147516-85-6

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10 mg USD 295 In-stock
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Based on 1 publication(s) in Google Scholar

C-Reactive Protein (CRP) (174-185) Related Antibodies

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Description

C-Reactive Protein (CRP) is an anti-pneumococcal plasma protein that can serve as an inflammatory marker. C-Reactive protein can protect mice from pneumococcal infection by activating complement. C-Reactive protein can inhibit the activation of caspase-3/9 through the CD64/AKT/mTOR pathway, thereby promoting chemotherapy resistance in mice with tongue squamous cell carcinoma[1][5].
In Vitro

C-Reactive Protein (CRP) (0-25 μg/mL; 24 h) promotes monocyte migration by stimulating 3T3-L1 adipocytes to produce CXCL7[3].
C-Reactive Protein (CRP) can impair G1/S-dependent regeneration of renal tubular epithelial cells[4].
C-Reactive Protein (CRP) (10 μg/mL, 4 days) can enhance TSCC cell viability and increase cell resistance to DDP[5].
C-Reactive Protein (CRP) is a highly structurally conserved major acute phase plasma protein in humans[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C-Reactive Protein (CRP) (174-185) Related Antibodies

Cell Migration Assay [3].

Cell Line: 3T3-L1 adipocytes
Concentration: 0-25 μg/mL
Incubation Time: 24 h
Result: Promoted cell migration.

Cell Viability Assay[5].

Cell Line: The human TSCC cell lines CAL27 and SCC4
Concentration: 10 μg/mL
Incubation Time: 4 days
Result: Improved TSCC cell viability.
In Vivo

C-Reactive Protein (CRP) (25 μg; once daily; 7 days; i.v.) can protect mice from pneumococcal infection by activating complement[1].
C-Reactive Protein (CRP) (20 mg/kg; once daily; 3 days; i.p.) can induce superoxide anion release and tissue factor activity in rat macrophages[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A murine model of pneumococcal infection[1].
Dosage: 25 μg
Administration: Intravenous injection (i.v.); once daily; 7 days
Result: Activated complement in mouse serum.
Animal Model: Male hooded Wistar rats (weighing 125-150 g)[2].
Dosage: 20 mg/kg
Administration: Intraperitoneal injection (i.p.); once daily; 3 days
Result: Upregulated PKC, NADPH oxidase, ERK, and JNK phosphorylation.
Molecular Weight

1276.48

Formula

C62H93N13O16
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ile-Tyr-Leu-Gly-Gly-Pro-Phe-Ser-Pro-Asn-Val-Leu
Sequence Shortening

IYLGGPFSPNVL
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
Purity & Documentation
References
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C-Reactive Protein (CRP) (174-185) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C-Reactive Protein (CRP) (174-185)147516-85-6AktmTORCaspasePKBProtein kinase BMammalian target of Rapamycincomplement activationpneumococcal bacteriachemotherapy resistanceInhibitorinhibitorinhibit

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