2. Cell Cycle/DNA Damage
  3. CDK
  4. CAF-382

CAF-382 (compound B1) is an analog of SNS-032 and a CDKL5 and pan-CDK inhibitor with a weak GSK3α/β affinity (>1.8 μM) and inhibitory activity. CAF-382 inhibits CDKL5 and blocks the phosphorylation of the CDKL5 E2 domain.

For research use only. We do not sell to patients.

CAF-382 Chemical Structure

CAF-382 Chemical Structure

Size Price Stock Quantity
1 mg USD 262 In-stock
5 mg USD 656 In-stock
10 mg USD 1050 In-stock
25 mg USD 2060 In-stock
50 mg USD 3300 In-stock
100 mg USD 4980 In-stock
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Based on 1 publication(s) in Google Scholar

CAF-382 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

CAF-382 (compound B1) is an analog of SNS-032 and a CDKL5 and pan-CDK inhibitor with a weak GSK3α/β affinity (>1.8 μM) and inhibitory activity. CAF-382 inhibits CDKL5 and blocks the phosphorylation of the CDKL5 E2 domain[1].

IC50 & Target

IC50: ≤100 nM (CDK9, PCTK1/CDK16, PCTK2/CDK17, PCTK3/CDK18), 2.1-2.7 μM (CDKL3, CDKL4)[1]
In Vitro

CAF-382 (compound B1) (5 nM-5 μM) causes a significant reduction in pSer222 EB2 at 5 nM without a change in total EB2 levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAF-382 Related Antibodies
Molecular Weight

366.50

Formula

C16H22N4O2S2
Appearance

Solid

Color

White to light yellow

SMILES

CC(C1=CN=C(O1)CSC2=CN=C(S2)NC(C3CCNCC3)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 3.33 mg/mL (9.09 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7285 mL 13.6426 mL 27.2851 mL
5 mM 0.5457 mL 2.7285 mL 5.4570 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.85%

COA (246 KB) HNMR (119 KB) LCMS (146 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7285 mL 13.6426 mL 27.2851 mL 68.2128 mL
5 mM 0.5457 mL 2.7285 mL 5.4570 mL 13.6426 mL
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CAF-382 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAF-382CAF382CAF 382CDKCyclin dependent kinaseCDKL5GSK3LTPhippocampusneuroscienceprotein kinaseratInhibitorinhibitorinhibit

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