Canthin-6-one

Cat. No.: HY-N3536 Purity: 99.92%: FAQs
Data Sheet SDS COA Handling Instructions

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Canthin-6-one displays a wide range of biological activities, such as antimycobacterial activity.

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Canthin-6-one Chemical Structure

CAS No. : 479-43-6

Size	Price	Stock	Quantity
1 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 700	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
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References
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Description

Canthin-6-one displays a wide range of biological activities, such as antimycobacterial activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	3.6 μg/mL Compound: 5	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 14575431]
ADR5000 cell line	IC₅₀	10.52 μM Compound: 25	Cytotoxicity against human multidrug-resistant CEM/ADR5000 cells assessed as fluorescence incubated for 72 hrs by resazurin reduction assay Cytotoxicity against human multidrug-resistant CEM/ADR5000 cells assessed as fluorescence incubated for 72 hrs by resazurin reduction assay	[PMID: 34332400]
C6	EC₅₀	15 μM Compound: 1	Antiproliferative activity against rat C6 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days Antiproliferative activity against rat C6 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days	[PMID: 25379743]
Calu-3	CC₅₀	> 100 μM Compound: Table 1, R11C2	Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
CCRF-CEM	IC₅₀	15.82 μM Compound: 25	Cytotoxicity against human drug sensitive CCRF-CEM cells assessed as fluorescence incubated for 72 hrs by resazurin reduction assay Cytotoxicity against human drug sensitive CCRF-CEM cells assessed as fluorescence incubated for 72 hrs by resazurin reduction assay	[PMID: 34332400]
DU-145	IC₅₀	9.43 μg/mL Compound: 25	Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay	[PMID: 34332400]
HCC1395	IC₅₀	8.12 μg/mL Compound: 25	Antiproliferative activity against human HCC1395 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HCC1395 cells incubated for 48 hrs by MTT assay	[PMID: 34332400]
HCT-8	CC₅₀	42.41 μM Compound: Table 1, R11C2	Cytotoxicity against human HCT-8 cells assessed as redcution in cell viability incubated for 96 hrs by PrestoBlue reagent based assay Cytotoxicity against human HCT-8 cells assessed as redcution in cell viability incubated for 96 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
HeLa	EC₅₀	15 μM Compound: 1	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days	[PMID: 25379743]
HepG2	CC₅₀	85.65 μM Compound: Table 1, R11C2	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
HT-29	EC₅₀	15 μM Compound: 1	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days	[PMID: 25379743]
Jurkat	EC₅₀	15 μM Compound: 1	Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days	[PMID: 25379743]
Keratinocyte	IC₅₀	1.11 μg/mL Compound: 25	Cytotoxicity against guinea pig ear keratinocytes using [3H]thymidine by liquid scintillation counting analysis Cytotoxicity against guinea pig ear keratinocytes using [3H]thymidine by liquid scintillation counting analysis	[PMID: 34332400]
MCF7	ED₅₀	7.3 μg/mL Compound: 5	Cytotoxicity against human MCF7 cells by SRB assay Cytotoxicity against human MCF7 cells by SRB assay	[PMID: 14575431]
MRC5	CC₅₀	91.16 μM Compound: Table 1, R11C2	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
NHDF	EC₅₀	115 μM Compound: 1	Toxicity against human NHDF assessed as reduction in cell viability incubated for 3 days by MTT assay Toxicity against human NHDF assessed as reduction in cell viability incubated for 3 days by MTT assay	[PMID: 25379743]
NIH3T3	EC₅₀	15 μM Compound: 1	Antiproliferative activity against mouse NIH/3T3 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days Antiproliferative activity against mouse NIH/3T3 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days	[PMID: 25379743]
PC-3	EC₅₀	15 μM Compound: 1	Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days	[PMID: 25379743]
Vero	CC₅₀	> 100 μM Compound: Table 1, R11C2	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay	[PMID: 36399766]

Molecular Weight

220.23

Formula

C₁₄H₈N₂O

CAS No.

479-43-6

Appearance

Solid

Color

White to light yellow

SMILES

O=C1N2C3=C(N=CC=C3C4=C2C=CC=C4)C=C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (113.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5407 mL	22.7035 mL	45.4071 mL
5 mM	0.9081 mL	4.5407 mL	9.0814 mL
10 mM	0.4541 mL	2.2704 mL	4.5407 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (261 KB) HNMR (318 KB) CNMR (302 KB) RP-HPLC (188 KB) MS (188 KB)

Handling Instructions (2659 KB)

References

[1]. O'Donnell G, Gibbons S. Antibacterial activity of two canthin-6-one alkaloids from Allium neapolitanum. Phytother Res. 2007;21(7):653-657. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.5407 mL	22.7035 mL	45.4071 mL	113.5177 mL
	5 mM	0.9081 mL	4.5407 mL	9.0814 mL	22.7035 mL
	10 mM	0.4541 mL	2.2704 mL	4.5407 mL	11.3518 mL
	15 mM	0.3027 mL	1.5136 mL	3.0271 mL	7.5678 mL
	20 mM	0.2270 mL	1.1352 mL	2.2704 mL	5.6759 mL
	25 mM	0.1816 mL	0.9081 mL	1.8163 mL	4.5407 mL
	30 mM	0.1514 mL	0.7568 mL	1.5136 mL	3.7839 mL
	40 mM	0.1135 mL	0.5676 mL	1.1352 mL	2.8379 mL
	50 mM	0.0908 mL	0.4541 mL	0.9081 mL	2.2704 mL
	60 mM	0.0757 mL	0.3784 mL	0.7568 mL	1.8920 mL
	80 mM	0.0568 mL	0.2838 mL	0.5676 mL	1.4190 mL
	100 mM	0.0454 mL	0.2270 mL	0.4541 mL	1.1352 mL

Canthin-6-one Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Canthin-6-one479-43-6BacterialInhibitorinhibitorinhibit

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Canthin-6-one

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