2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Carbazochrome

Carbazochrome is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome is an antihemorrhagic agent.

For research use only. We do not sell to patients.

Carbazochrome Chemical Structure

Carbazochrome Chemical Structure

CAS No. : 69-81-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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Based on 1 publication(s) in Google Scholar

Other Forms of Carbazochrome:

Carbazochrome Related Antibodies

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  • Biological Activity

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  • References

  • Customer Review

Description

Carbazochrome is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome is an antihemorrhagic agent[1].

In Vitro

Carbazochrome (0.1-10 µM) inhibits the Bradykinin induced and thrombin-induced formation of [3H]IP3 in a concentration-dependent manner[1]. Carbazochrome (0.1-1 µM), when included from 30 min before stimulation, significantly suppressed the enhancement of permeability induced by vasoactive substances[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Carbazochrome Related Antibodies
In Vivo

Carbazochrome inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media. Carbazochrome (1-10 mg/kg, i.v.) attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats weighing 180-230 g[2]
Dosage: 10 mg/kg
Administration: I.v.; injected 30, 60, or 90 min before Ioxaglate injection (4 g I/kg, i.v.).
Result: Attenuated the Ioxaglate-increased vascular permeability at the dose of 1, 5 and 10 mg/kg in a dose-dependent manner, achieving statistical significance at 5 and 10 mg/kg.
Molecular Weight

236.23

Formula

C10H12N4O3
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C1/C(C=C2C(O)CN(C)C2=C1)=N\NC(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (21.17 mM; ultrasonic and adjust pH to 12 with NaOH)

DMSO : 4 mg/mL (16.93 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2332 mL 21.1658 mL 42.3316 mL
5 mM 0.8466 mL 4.2332 mL 8.4663 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.94%

SDS (393 KB)

COA (248 KB) HNMR (132 KB) LCMS (92 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 4.2332 mL 21.1658 mL 42.3316 mL 105.8291 mL
5 mM 0.8466 mL 4.2332 mL 8.4663 mL 21.1658 mL
10 mM 0.4233 mL 2.1166 mL 4.2332 mL 10.5829 mL
15 mM 0.2822 mL 1.4111 mL 2.8221 mL 7.0553 mL
H2O 20 mM 0.2117 mL 1.0583 mL 2.1166 mL 5.2915 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Carbazochrome Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carbazochrome69-81-8Adrenergic ReceptorBeta ReceptorcapillarystabiliserhaemorrhageantihemorrhagicInhibitorinhibitorinhibit

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