1. NF-κB Cell Cycle/DNA Damage Apoptosis
  2. NF-κB PERK Keap1-Nrf2 Apoptosis
  3. Carbocisteine

Carbocisteine  (Synonyms: Carbocysteine)

Cat. No.: HY-D0205A Purity: ≥98.0%
Handling Instructions Technical Support

Carbocisteine is an orally active mucolytic agent. Carbocisteine attenuates the phosphorylation of NF-κB p65 and ERK1/2. Carbocisteine modulates Nrf2/HO-1 and NFκB interplay. Carbocisteine inhibits Apoptosis. Carbocisteine is used in chronic obstructive pulmonary disease (COPD) research.

For research use only. We do not sell to patients.

Carbocisteine Chemical Structure

Carbocisteine Chemical Structure

CAS No. : 638-23-3

Size Price Stock Quantity
500 mg In-stock
1 g In-stock
5 g   Get quote  
10 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Carbocisteine:

Top Publications Citing Use of Products

View All NF-κB Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Carbocisteine is an orally active mucolytic agent. Carbocisteine attenuates the phosphorylation of NF-κB p65 and ERK1/2. Carbocisteine modulates Nrf2/HO-1 and NFκB interplay. Carbocisteine inhibits Apoptosis. Carbocisteine is used in chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5][6][7][8][9][10][11][12][13].

In Vitro

Carbocisteine (10-1000 μM, 24 h) attenuates hydrogen peroxide-induced inflammatory injury in A549 cells via NF-κB and ERK1/2 MAPK pathways[4].
Carbocisteine (L-Carbocisteine, 10 μM, from 3 days before infection) shows inhibitory effects on type A seasonal influenza virus infection in human airway epithelial cells[5].
Carbocisteine (L-carbocisteine, 10 μM, 72 h) inhibits oxidant-induced apoptosis in cultured human airway epithelial cells[12].
Carbocisteine (10-1000 μM, 24 h) attenuates TNF-α-induced inflammation in human alveolar epithelial cells in vitro through suppressing NF-κB and ERK1/2 MAPK signaling pathways[13].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Carbocisteine (100 mg/kg, oral gavage, twice daily from 1 day before CS exposure until the end of the experiment) reduces virus-induced pulmonary inflammation in mice exposed to cigarette smoke[2].
. Carbocisteine (100 mg/kg, p.o.) promotes phagocytosis of apoptotic cells by alveolar macrophages in BALB/c mice[3].
. Carbocisteine (125-250 mg/kg/d, gavage, once a week for 3 weeks) protects against emphysema induced by cigarette smoke extract in rats[6].
Carbocisteine (500 mg/kg/day, p.o., in two divided doses, 2 days) inhibits oxidative stress, inflammatory response, and apoptosis in acetic acid-induced UC by modulating the Nrf2/HO-1 and NFκB interplay in rats[7].
Carbocisteine (112.5-225 mg/kg/d, gavage, 12 weeks) inhibits the expression of Muc5b in COPD mouse model[8].
Carbocisteine (300 mg/kg, i.g., once every day for the last 6 weeks) ameliorates steroid resistance in rat COPD model[9].
Carbocisteine (250 mg/kg ×2/day, p.o., 25 days) inhibits the changes in these enzyme (fucosidase, sialidase, fucosyltransferase and sialyltransferase) activities and the expressions of Muc5ac mRNA and protein in the lungin SO2-exposed rats[10].
Carbocysteine (300 mg/kg, p.o., every day both from week 6 to week 12 of smoke exposure) restores steroid sensitivity by targeting histone deacetylase 2 in a thiol/GSH-dependent manner in rats[11].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

179.19

Formula

C5H9NO4S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CSCC(O)=O)C(O)=O

Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 2 mg/mL (11.16 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5807 mL 27.9033 mL 55.8067 mL
5 mM 1.1161 mL 5.5807 mL 11.1613 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 2 mg/mL (11.16 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.5807 mL 27.9033 mL 55.8067 mL 139.5167 mL
5 mM 1.1161 mL 5.5807 mL 11.1613 mL 27.9033 mL
10 mM 0.5581 mL 2.7903 mL 5.5807 mL 13.9517 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Carbocisteine
Cat. No.:
HY-D0205A
Quantity:
MCE Japan Authorized Agent: