Cathepsin inhibitor 1

Name: Cathepsin inhibitor 1
Brand: MedChemExpress
SKU: HY-100231
Rating: 4.5 (1 reviews)

Cat. No.: HY-100231 Purity: 98.89%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Cathepsin inhibitor 1 (Compound 25) is a potent and selective inhibitor of Cathepsin, with pIC₅₀s of 7.9, 6.7, 6.0, 5.5 and 5.2 for CatL, CatL2, CatS, CatK, and CatB, respectively. Cathepsin inhibitor 1 is promising for research of osteoarthritis.

For research use only. We do not sell to patients.

Cathepsin inhibitor 1 Chemical Structure

CAS No. : 225120-65-0

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 132	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 132	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 680	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1100	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Cathepsin Isoform Specific Products:

View All Isoforms

Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

The CatL pIC₅₀ value of Cathepsin inhibitor 1^[1]

Compd	CatL pIC₅₀	CatL2 pIC₅₀	CatS pIC₅₀	CatK pIC₅₀	CatB pIC₅₀
Cathepsin inhibitor 1	7.9	6.7	6.0	5.5	5.2

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

401.89

Formula

C₂₀H₂₄ClN₅O₂

CAS No.

225120-65-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(C(C)(C)C)=NN1C)N[C@@H](CC2=CC=CC(Cl)=C2)C(NCC#N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (248.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4882 mL	12.4412 mL	24.8824 mL
5 mM	0.4976 mL	2.4882 mL	4.9765 mL
10 mM	0.2488 mL	1.2441 mL	2.4882 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.89%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (249 KB) HNMR (254 KB) LCMS (86 KB)

Handling Instructions (2659 KB)

References

[1]. Asaad N, et, al. Dipeptidyl nitrile inhibitors of Cathepsin L. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4280-3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4882 mL	12.4412 mL	24.8824 mL	62.2061 mL
	5 mM	0.4976 mL	2.4882 mL	4.9765 mL	12.4412 mL
	10 mM	0.2488 mL	1.2441 mL	2.4882 mL	6.2206 mL
	15 mM	0.1659 mL	0.8294 mL	1.6588 mL	4.1471 mL
	20 mM	0.1244 mL	0.6221 mL	1.2441 mL	3.1103 mL
	25 mM	0.0995 mL	0.4976 mL	0.9953 mL	2.4882 mL
	30 mM	0.0829 mL	0.4147 mL	0.8294 mL	2.0735 mL
	40 mM	0.0622 mL	0.3110 mL	0.6221 mL	1.5552 mL
	50 mM	0.0498 mL	0.2488 mL	0.4976 mL	1.2441 mL
	60 mM	0.0415 mL	0.2074 mL	0.4147 mL	1.0368 mL
	80 mM	0.0311 mL	0.1555 mL	0.3110 mL	0.7776 mL
	100 mM	0.0249 mL	0.1244 mL	0.2488 mL	0.6221 mL