2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. Cathepsin inhibitor 1

Cathepsin inhibitor 1 (Compound 25) is a potent and selective inhibitor of Cathepsin, with pIC50s of 7.9, 6.7, 6.0, 5.5 and 5.2 for CatL, CatL2, CatS, CatK, and CatB, respectively. Cathepsin inhibitor 1 is promising for research of osteoarthritis.

For research use only. We do not sell to patients.

Cathepsin inhibitor 1 Chemical Structure

Cathepsin inhibitor 1 Chemical Structure

CAS No. : 225120-65-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 132 In-stock
Solution
10 mM * 1 mL in DMSO USD 132 In-stock
Solid
5 mg USD 120 In-stock
10 mg USD 190 In-stock
50 mg USD 680 In-stock
100 mg USD 1100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Cathepsin inhibitor 1 Related Antibodies

Top Publications Citing Use of Products

View All Cathepsin Isoform Specific Products:

View All Isoforms
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Cathepsin inhibitor 1 (Compound 25) is a potent and selective inhibitor of Cathepsin, with pIC50s of 7.9, 6.7, 6.0, 5.5 and 5.2 for CatL, CatL2, CatS, CatK, and CatB, respectively. Cathepsin inhibitor 1 is promising for research of osteoarthritis[1].

In Vitro


The CatL pIC50 value of Cathepsin inhibitor 1[1]

Compd CatL pIC50 CatL2 pIC50 CatS pIC50 CatK pIC50 CatB pIC50
Cathepsin inhibitor 1 7.9 6.7 6.0 5.5 5.2

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cathepsin inhibitor 1 Related Antibodies
Molecular Weight

401.89

Formula

C20H24ClN5O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(C(C)(C)C)=NN1C)N[C@@H](CC2=CC=CC(Cl)=C2)C(NCC#N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (248.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4882 mL 12.4412 mL 24.8824 mL
5 mM 0.4976 mL 2.4882 mL 4.9765 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.89%

COA (249 KB) HNMR (254 KB) LCMS (86 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4882 mL 12.4412 mL 24.8824 mL 62.2061 mL
5 mM 0.4976 mL 2.4882 mL 4.9765 mL 12.4412 mL
10 mM 0.2488 mL 1.2441 mL 2.4882 mL 6.2206 mL
15 mM 0.1659 mL 0.8294 mL 1.6588 mL 4.1471 mL
20 mM 0.1244 mL 0.6221 mL 1.2441 mL 3.1103 mL
25 mM 0.0995 mL 0.4976 mL 0.9953 mL 2.4882 mL
30 mM 0.0829 mL 0.4147 mL 0.8294 mL 2.0735 mL
40 mM 0.0622 mL 0.3110 mL 0.6221 mL 1.5552 mL
50 mM 0.0498 mL 0.2488 mL 0.4976 mL 1.2441 mL
60 mM 0.0415 mL 0.2074 mL 0.4147 mL 1.0368 mL
80 mM 0.0311 mL 0.1555 mL 0.3110 mL 0.7776 mL
100 mM 0.0249 mL 0.1244 mL 0.2488 mL 0.6221 mL
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Cathepsin inhibitor 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cathepsin inhibitor 1225120-65-0Cathepsin inhibitor1Cathepsin inhibitor-1CathepsinCatLCatL2CatSCatKCatBInhibitorinhibitorinhibit

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