2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. CB07-Exatecan

CB07-Exatecan is an ADC drug-Linker conjugate that can be used for the synthesis of ADCs. ADC conjugated with CB07-Exatecan and trastuzumab inhibits the growth of HER2-positive cancer cells. CB07-Exatecan can be used in cancer research.

For research use only. We do not sell to patients.

CB07-Exatecan Chemical Structure

CB07-Exatecan Chemical Structure

CAS No. : 2879247-31-9

Size Price Stock Quantity
1 mg USD 963 In-stock
5 mg USD 2120 In-stock
10 mg USD 3400 In-stock
25 mg USD 6460 In-stock
50 mg USD 9600 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

CB07-Exatecan Related Antibodies

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

  • Biological Activity

  • Purity & Documentation

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Description

CB07-Exatecan is an ADC drug-Linker conjugate that can be used for the synthesis of ADCs. ADC conjugated with CB07-Exatecan and trastuzumab inhibits the growth of HER2-positive cancer cells. CB07-Exatecan can be used in cancer research[1].

IC50 & Target

Camptothecins

 

Molecular Weight

1472.56

Formula

C71H94FN11O22
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C=CC1=O)N1CC(N[C@@H](CCNC(CCOCCOCCOCCOCCOCCOCCOCCOC)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C2)=CC=C2COC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (67.91 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6791 mL 3.3954 mL 6.7909 mL
5 mM 0.1358 mL 0.6791 mL 1.3582 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6791 mL 3.3954 mL 6.7909 mL 16.9772 mL
5 mM 0.1358 mL 0.6791 mL 1.3582 mL 3.3954 mL
10 mM 0.0679 mL 0.3395 mL 0.6791 mL 1.6977 mL
15 mM 0.0453 mL 0.2264 mL 0.4527 mL 1.1318 mL
20 mM 0.0340 mL 0.1698 mL 0.3395 mL 0.8489 mL
25 mM 0.0272 mL 0.1358 mL 0.2716 mL 0.6791 mL
30 mM 0.0226 mL 0.1132 mL 0.2264 mL 0.5659 mL
40 mM 0.0170 mL 0.0849 mL 0.1698 mL 0.4244 mL
50 mM 0.0136 mL 0.0679 mL 0.1358 mL 0.3395 mL
60 mM 0.0113 mL 0.0566 mL 0.1132 mL 0.2830 mL
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CB07-Exatecan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB07-Exatecan2879247-31-9Drug-Linker Conjugates for ADCTopoisomeraseHER2tumorcancersolid tumorADCTrastuzumabInhibitorinhibitorinhibit

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