2. Epigenetics
  3. Histone Acetyltransferase
  4. CBP/p300-IN-19 hydrochloride

CBP/p300-IN-19 hydrochloride is a potent and selective p300/CBP HAT inhibitor with IC50s of 1.4, 2.2, >100, >100 µM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 hydrochloride shows antitumor activity.

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CBP/p300-IN-19 hydrochloride Chemical Structure

CBP/p300-IN-19 hydrochloride Chemical Structure

CAS No. : 2592638-14-5

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Based on 1 publication(s) in Google Scholar

Other Forms of CBP/p300-IN-19 hydrochloride:

CBP/p300-IN-19 hydrochloride Related Antibodies

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Description

CBP/p300-IN-19 hydrochloride is a potent and selective p300/CBP HAT inhibitor with IC50s of 1.4, 2.2, >100, >100 µM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 hydrochloride shows antitumor activity[1].

IC50 & Target[1]

Myst3

>100 μM (IC50)

p300-HAT

1.4 μM (IC50)

CBP-HAT

2.2 μM (IC50)

PCAF

>100 μM (IC50)

In Vitro

CBP/p300-IN-19 hydrochloride (compound 29) shows antiproliferative activity with EC50s of 5.3, 8.5, 6.2, 4.4, 1.2, 4.3, 3.6, 8.7, 6.4 µM for MCF-7, MDA-MB231, LNCaP, PC-3, PANC-1, MDA-PANC-28, Molm-13, MV4;11, RPMI-8226 cells, respectively[1].
CBP/p300-IN-19 hydrochloride (0, 5, 10 µM; 12 h) dose-dependenly inhibits the acetylation of H3K18, H3K9 and K27[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CBP/p300-IN-19 hydrochloride Related Antibodies

Western Blot Analysis[1]

Cell Line: Kasumi-1 leukemia cells
Concentration: 0, 5, 10 µM
Incubation Time: 12 h
Result: Dose-dependently inhibited the acetylation of H3K18, H3K9 and K27.
Molecular Weight

514.01

Formula

C30H28ClN3O3
CAS No.
SMILES

[H]Cl.C1(C2=CC=C(C3=COC=C3)C=C2)=NC=C(OCC4CCNCC4)N=C1C5=CC=C(C6=COC=C6)C=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CBP/p300-IN-19 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBP/p300-IN-192592638-14-5Histone AcetyltransferaseHATsHATanticancerKasumi-1 leukemia cellsantiproliferativeMCF-7 cellschemical probeInhibitorinhibitorinhibit

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