CDK1/Cyc B-IN-1

Name: CDK1/Cyc B-IN-1
Brand: MedChemExpress
SKU: HY-147646
Rating: 4.5 (1 reviews)

Cat. No.: HY-147646 Purity: 98.47%: FAQs
Data Sheet SDS COA Handling Instructions

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CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC₅₀ of 97 nM. CDK1/Cyc B-IN-1 triggers apoptosis and G2/M cell cycle arrest. CDK1/Cyc B-IN-1 shows broad-spectrum cytotoxic action against cancer cell lines.

For research use only. We do not sell to patients.

CDK1/Cyc B-IN-1 Chemical Structure

CAS No. : 2459916-56-2

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

CDK1-Cyclin B

97 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	4.47 μM Compound: 5	Antiproliferative activity against human 786-0 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human 786-0 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
A498	GI₅₀	11.48 μM Compound: 5	Antiproliferative activity against human A498 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human A498 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
A549	GI₅₀	4.47 μM Compound: 5	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
ACHN	GI₅₀	2.09 μM Compound: 5	Antiproliferative activity against human ACHN cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human ACHN cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
BT-549	GI₅₀	2 μM Compound: 5	Antiproliferative activity against human BT-549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human BT-549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
CAKI-1	GI₅₀	6.17 μM Compound: 5	Antiproliferative activity against human CAKI-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human CAKI-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
CCRF-CEM	GI₅₀	2.69 μM Compound: 5	Antiproliferative activity against human CCRF-CEM cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human CCRF-CEM cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
COLO 205	GI₅₀	3.8 μM Compound: 5	Antiproliferative activity against human COLO 205 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human COLO 205 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
DU-145	GI₅₀	1.86 μM Compound: 5	Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
EKVX	GI₅₀	4.57 μM Compound: 5	Antiproliferative activity against human EKVX cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human EKVX cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
HCC 2998	GI₅₀	16.22 μM Compound: 5	Antiproliferative activity against human HCC 2998 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human HCC 2998 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
HCT-116	GI₅₀	1.82 μM Compound: 5	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
HCT-116	IC₅₀	5.34 μM Compound: 5	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32773088]
HCT-15	GI₅₀	1.95 μM Compound: 5	Antiproliferative activity against human HCT-15 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human HCT-15 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
HL-60(TB)	GI₅₀	1.41 μM Compound: 5	Antiproliferative activity against human HL-60(TB) cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human HL-60(TB) cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
HOP-62	GI₅₀	2.57 μM Compound: 5	Antiproliferative activity against human HOP-62 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human HOP-62 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
HOP-92	GI₅₀	2.04 μM Compound: 5	Antiproliferative activity against human HOP-92 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human HOP-92 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
Hs-578T	GI₅₀	2.63 μM Compound: 5	Antiproliferative activity against human Hs-578T cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human Hs-578T cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
HT-29	GI₅₀	2.4 μM Compound: 5	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
IGROV-1	GI₅₀	1.95 μM Compound: 5	Antiproliferative activity against human IGROV-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human IGROV-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
K562	GI₅₀	1.2 μM Compound: 5	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
KM12	GI₅₀	3.31 μM Compound: 5	Antiproliferative activity against human KM12 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human KM12 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
LOX IMVI	GI₅₀	1.7 μM Compound: 5	Antiproliferative activity against human LOX IMVI cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human LOX IMVI cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
M14	GI₅₀	1.86 μM Compound: 5	Antiproliferative activity against human M14 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human M14 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
Malme-3M	GI₅₀	2.24 μM Compound: 5	Antiproliferative activity against human Malme-3M cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human Malme-3M cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
MCF7	GI₅₀	3.63 μM Compound: 5	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
MDA-MB-231	GI₅₀	3.16 μM Compound: 5	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
MDA-MB-435	GI₅₀	2.14 μM Compound: 5	Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
MDA-MB-468	GI₅₀	2 μM Compound: 5	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
MOLT-4	GI₅₀	2.14 μM Compound: 5	Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
NCI/ADR-RES	GI₅₀	13.18 μM Compound: 5	Antiproliferative activity against human NCI/ADR-RES cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human NCI/ADR-RES cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
NCI-H226	GI₅₀	3.24 μM Compound: 5	Antiproliferative activity against human NCI-H226 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human NCI-H226 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
NCI-H23	GI₅₀	2.45 μM Compound: 5	Antiproliferative activity against human NCI-H23 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human NCI-H23 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
NCI-H322M	GI₅₀	2.51 μM Compound: 5	Antiproliferative activity against human NCI-H322M cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human NCI-H322M cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
NCI-H460	GI₅₀	3.09 μM Compound: 5	Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
NCI-H522	GI₅₀	1.82 μM Compound: 5	Antiproliferative activity against human NCI-H522 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human NCI-H522 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
OVCAR-3	GI₅₀	1.78 μM Compound: 5	Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
OVCAR-4	GI₅₀	4.68 μM Compound: 5	Antiproliferative activity against human OVCAR-4 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human OVCAR-4 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
OVCAR-5	GI₅₀	6.17 μM Compound: 5	Antiproliferative activity against human OVCAR-5 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human OVCAR-5 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
OVCAR-8	GI₅₀	2.69 μM Compound: 5	Antiproliferative activity against human OVCAR-8 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human OVCAR-8 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
PC-3	GI₅₀	2.4 μM Compound: 5	Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
RPMI-8226	GI₅₀	3.47 μM Compound: 5	Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
RXF 393	GI₅₀	2 μM Compound: 5	Antiproliferative activity against human RXF 393 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human RXF 393 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SF-268	GI₅₀	2.19 μM Compound: 5	Antiproliferative activity against human SF-268 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SF-268 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SF-295	GI₅₀	7.08 μM Compound: 5	Antiproliferative activity against human SF-295 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SF-295 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SF-539	GI₅₀	2.09 μM Compound: 5	Antiproliferative activity against human SF-539 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SF-539 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SK-MEL-2	GI₅₀	2.04 μM Compound: 5	Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SK-MEL-28	GI₅₀	2.19 μM Compound: 5	Antiproliferative activity against human SK-MEL-28 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SK-MEL-28 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SK-OV-3	GI₅₀	14.13 μM Compound: 5	Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SN12C	GI₅₀	2.82 μM Compound: 5	Antiproliferative activity against human SN12C cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SN12C cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SNB-19	GI₅₀	2.4 μM Compound: 5	Antiproliferative activity against human SNB-19 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SNB-19 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SNB-75	GI₅₀	1.95 μM Compound: 5	Antiproliferative activity against human SNB-75 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SNB-75 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SR	GI₅₀	1.41 μM Compound: 5	Antiproliferative activity against human SR cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SR cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SW-620	GI₅₀	2.57 μM Compound: 5	Antiproliferative activity against human SW-620 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SW-620 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
T47D	GI₅₀	6.46 μM Compound: 5	Antiproliferative activity against human T47D cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human T47D cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
TK-10	GI₅₀	4.68 μM Compound: 5	Antiproliferative activity against human TK-10 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human TK-10 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
U-251	GI₅₀	1.91 μM Compound: 5	Antiproliferative activity against human U-251 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human U-251 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
UACC-257	GI₅₀	2.34 μM Compound: 5	Antiproliferative activity against human UACC-257 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human UACC-257 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
UACC-62	GI₅₀	2.04 μM Compound: 5	Antiproliferative activity against human UACC-62 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human UACC-62 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
UO-31	GI₅₀	3.63 μM Compound: 5	Antiproliferative activity against human UO-31 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human UO-31 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
WI-38	IC₅₀	21.7 μM Compound: 5	Cytotoxicity against human WI-38 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human WI-38 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32773088]

In Vitro

CDK1/Cyc B-IN-1 (Compound 5) shows cytotoxic activity with IC₅₀ values of 5.33 ± 0.69 µM and 21.69 ± 1.04 µM against HCT-116 and WI-38, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

353.85

Formula

C₁₄H₁₂ClN₃O₂S₂

CAS No.

2459916-56-2

Appearance

Solid

Color

Light yellow to brown

SMILES

COC1=CC=C(C(OC)=C1)N2C(SC3=C2N=C(N=C3Cl)C)=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (282.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8261 mL	14.1303 mL	28.2606 mL
5 mM	0.5652 mL	2.8261 mL	5.6521 mL
10 mM	0.2826 mL	1.4130 mL	2.8261 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.07 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.47%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (256 KB) HNMR (158 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Mohamed SH, et al. An investigative study of antitumor properties of a novel thiazolo[4,5-d]pyrimidine small molecule revealing superior antitumor activity with CDK1 selectivity and potent pro-apoptotic properties. Bioorg Med Chem. 2020 Sep 1;28(17):11563 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8261 mL	14.1303 mL	28.2606 mL	70.6514 mL
	5 mM	0.5652 mL	2.8261 mL	5.6521 mL	14.1303 mL
	10 mM	0.2826 mL	1.4130 mL	2.8261 mL	7.0651 mL
	15 mM	0.1884 mL	0.9420 mL	1.8840 mL	4.7101 mL
	20 mM	0.1413 mL	0.7065 mL	1.4130 mL	3.5326 mL
	25 mM	0.1130 mL	0.5652 mL	1.1304 mL	2.8261 mL
	30 mM	0.0942 mL	0.4710 mL	0.9420 mL	2.3550 mL
	40 mM	0.0707 mL	0.3533 mL	0.7065 mL	1.7663 mL
	50 mM	0.0565 mL	0.2826 mL	0.5652 mL	1.4130 mL
	60 mM	0.0471 mL	0.2355 mL	0.4710 mL	1.1775 mL
	80 mM	0.0353 mL	0.1766 mL	0.3533 mL	0.8831 mL
	100 mM	0.0283 mL	0.1413 mL	0.2826 mL	0.7065 mL

CDK1/Cyc B-IN-1 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK1/Cyc B-IN-12459916-56-2CDKApoptosisCyclin dependent kinaseanticancer activityHCT-116WI-38p53BAXcytochrome ccaspases-3caspases-8caspases-9Bcl-2Inhibitorinhibitorinhibit

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CDK1/Cyc B-IN-1

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References

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Complete Stock Solution Preparation Table

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