2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK2-IN-22

CDK2-IN-22 (compound 7I) is a potent CDK2 inhibitor with an IC50 of 64.42 nM. CDK2-IN-22 presents a broad antiproliferative efficacy toward diverse cancer cells MV4-11, HT-29, MCF-7, and HeLa with IC50 values of 0.83 μM, 2.12 μM, 3.12 μM, and 8.61 μM, respectively.

For research use only. We do not sell to patients.

CDK2-IN-22 Chemical Structure

CDK2-IN-22 Chemical Structure

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5 mg USD 110 In-stock
10 mg USD 175 In-stock
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50 mg USD 560 In-stock
100 mg USD 890 In-stock
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Based on 1 publication(s) in Google Scholar

CDK2-IN-22 Related Antibodies

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Description

CDK2-IN-22 (compound 7I) is a potent CDK2 inhibitor with an IC50 of 64.42 nM. CDK2-IN-22 presents a broad antiproliferative efficacy toward diverse cancer cells MV4-11, HT-29, MCF-7, and HeLa with IC50 values of 0.83 μM, 2.12 μM, 3.12 μM, and 8.61 μM, respectively[1].

IC50 & Target[1]

CDK2

64.42 nM (IC50)

Molecular Weight

434.47

Formula

C21H18N6O3S
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(NC2=NC=CC(NC3=CC(OC4=CC=CC=C4)=CN=C3)=N2)C=C1)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (575.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3017 mL 11.5083 mL 23.0165 mL
5 mM 0.4603 mL 2.3017 mL 4.6033 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3017 mL 11.5083 mL 23.0165 mL 57.5414 mL
5 mM 0.4603 mL 2.3017 mL 4.6033 mL 11.5083 mL
10 mM 0.2302 mL 1.1508 mL 2.3017 mL 5.7541 mL
15 mM 0.1534 mL 0.7672 mL 1.5344 mL 3.8361 mL
20 mM 0.1151 mL 0.5754 mL 1.1508 mL 2.8771 mL
25 mM 0.0921 mL 0.4603 mL 0.9207 mL 2.3017 mL
30 mM 0.0767 mL 0.3836 mL 0.7672 mL 1.9180 mL
40 mM 0.0575 mL 0.2877 mL 0.5754 mL 1.4385 mL
50 mM 0.0460 mL 0.2302 mL 0.4603 mL 1.1508 mL
60 mM 0.0384 mL 0.1918 mL 0.3836 mL 0.9590 mL
80 mM 0.0288 mL 0.1439 mL 0.2877 mL 0.7193 mL
100 mM 0.0230 mL 0.1151 mL 0.2302 mL 0.5754 mL
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CDK2-IN-22 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2-IN-22CDKCyclin dependent kinaseCDK2 inhibitorMV4-11HT-29MCF-7HeLaantiproliferative efficacyInhibitorinhibitorinhibit

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