2. PROTAC Cell Cycle/DNA Damage
  3. PROTACs CDK
  4. BSJ-02-162

BSJ-02-162  (Synonyms: CDK4/6-IN-11)

Cat. No.: HY-144995 Purity: 96.87%
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CDK4/6-IN-11 is a potent PROTAC CDK4/6 degrader. CDK4/6-IN-11 consists of a thalidomide-based E3 ligase ligand (blue part) Thalidomide-NH-CH2-COOH (HY-131717), a target protein ligand (red part) Palbociclib (HY-50767), and a PROTAC linker (black part) Boc-NH-C4-Br (HY-W007803). E3 ligase ligand and linker can form Thalidomide-NH-amido-C4-Br (HY-170307).

For research use only. We do not sell to patients.

BSJ-02-162 Chemical Structure

BSJ-02-162 Chemical Structure

CAS No. : 2139329-47-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 330 In-stock
Solution
10 mM * 1 mL in DMSO USD 330 In-stock
Solid
5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 950 In-stock
50 mg USD 1450 In-stock
100 mg USD 2250 In-stock
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Based on 1 publication(s) in Google Scholar

BSJ-02-162 Related Antibodies

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Description

CDK4/6-IN-11 is a potent PROTAC CDK4/6 degrader[1]. CDK4/6-IN-11 consists of a thalidomide-based E3 ligase ligand (blue part) Thalidomide-NH-CH2-COOH (HY-131717), a target protein ligand (red part) Palbociclib (HY-50767), and a PROTAC linker (black part) Boc-NH-C4-Br (HY-W007803). E3 ligase ligand and linker can form Thalidomide-NH-amido-C4-Br (HY-170307).

Molecular Weight

831.92

Formula

C43H49N11O7
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NCCCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)CNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (30.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2020 mL 6.0102 mL 12.0204 mL
5 mM 0.2404 mL 1.2020 mL 2.4041 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2020 mL 6.0102 mL 12.0204 mL 30.0510 mL
5 mM 0.2404 mL 1.2020 mL 2.4041 mL 6.0102 mL
10 mM 0.1202 mL 0.6010 mL 1.2020 mL 3.0051 mL
15 mM 0.0801 mL 0.4007 mL 0.8014 mL 2.0034 mL
20 mM 0.0601 mL 0.3005 mL 0.6010 mL 1.5025 mL
25 mM 0.0481 mL 0.2404 mL 0.4808 mL 1.2020 mL
30 mM 0.0401 mL 0.2003 mL 0.4007 mL 1.0017 mL
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BSJ-02-162 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BSJ-02-1622139329-47-6CDK4/6-IN-11PROTACsCDKCyclin dependent kinaseInhibitorinhibitorinhibit

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