Cereblon inhibitor 1

Name: Cereblon inhibitor 1
Brand: MedChemExpress
SKU: HY-143715
Rating: 4.5 (1 reviews)

Cat. No.: HY-143715 Purity: 99.19%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Cereblon inhibitor 1, an isoindoline derivative, is a cereblon E3 ubiquitin ligase modulating agent. Cereblon inhibitor 1 has the potential for cancer research.

For research use only. We do not sell to patients.

Cereblon inhibitor 1 Chemical Structure

CAS No. : 2672489-14-2

Size	Price	Stock	Quantity
5 mg	USD 840	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1345	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 2690	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 4310	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 6900	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cereblon inhibitor 1, an isoindoline derivative, is a cereblon E3 ubiquitin ligase modulating agent. Cereblon inhibitor 1 has the potential for cancer research.

IC₅₀ & Target^[1]

Cereblon

In Vitro

Cereblon inhibitor 1 (compound CM-48) suppresses MM.1S cell proliferation (IC₅₀=0.0365 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

620.05

Formula

C₃₂H₂₈ClF₂N₅O₄

CAS No.

2672489-14-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

N#CC1=CC=C(N2CCN(CC3=CC=C(COC4=CC=CC5=C4CN([C@@H](CC6)C(NC6=O)=O)C5=O)C(F)=C3)CC2)C(F)=C1Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (161.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6128 mL	8.0639 mL	16.1277 mL
5 mM	0.3226 mL	1.6128 mL	3.2255 mL
10 mM	0.1613 mL	0.8064 mL	1.6128 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.19%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (251 KB) HNMR (478 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Hui Liu, et al. Isoindoline derivative and its application. WO2021147889A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6128 mL	8.0639 mL	16.1277 mL	40.3193 mL
	5 mM	0.3226 mL	1.6128 mL	3.2255 mL	8.0639 mL
	10 mM	0.1613 mL	0.8064 mL	1.6128 mL	4.0319 mL
	15 mM	0.1075 mL	0.5376 mL	1.0752 mL	2.6880 mL
	20 mM	0.0806 mL	0.4032 mL	0.8064 mL	2.0160 mL
	25 mM	0.0645 mL	0.3226 mL	0.6451 mL	1.6128 mL
	30 mM	0.0538 mL	0.2688 mL	0.5376 mL	1.3440 mL
	40 mM	0.0403 mL	0.2016 mL	0.4032 mL	1.0080 mL
	50 mM	0.0323 mL	0.1613 mL	0.3226 mL	0.8064 mL
	60 mM	0.0269 mL	0.1344 mL	0.2688 mL	0.6720 mL
	80 mM	0.0202 mL	0.1008 mL	0.2016 mL	0.5040 mL
	100 mM	0.0161 mL	0.0806 mL	0.1613 mL	0.4032 mL