2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Reactive Oxygen Species Apoptosis
  4. Chicoric acid

Chicoric acid  (Synonyms: Cichoric acid; Dicaffeoyltartaric acid)

Cat. No.: HY-N0457 Purity: 99.95%
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Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects.

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Chicoric acid Chemical Structure

Chicoric acid Chemical Structure

CAS No. : 6537-80-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 79 In-stock
Solution
10 mM * 1 mL in Water USD 79 In-stock
Solid
5 mg USD 46 In-stock
10 mg USD 72 In-stock
25 mg USD 144 In-stock
50 mg USD 252 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Chicoric acid:

Chicoric acid Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Chicoric acid

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  • Purity & Documentation

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Description

Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects[1][2][3].

In Vitro

Chicoric acid (Cichoric acid; 10-200 μM; for 24, 48, and 72 h) causes a dose- and time-dependent decrease in cell viability[1].
? Chicoric acid (100 μM; 48 h) induces apoptosis through caspase-3-dependent pathway[1].
? Chicoric acid (100 μM; 48 h) decreases the protein level of p-Akt[1].
? Chicoric acid (25, 50, 100 μM; for 24 hours) dramatically improves glucose uptake in a dose-dependent manner, and Chicoric acid further enhances insulin-induced (100 nM; 30 min) glucose uptake by 57.7% in HepG2 cells[2].
? Chicoric acid (100 μM; for 24 hours) restores glucosamine-induced impairment of GLUT2 translocation through activating PI3K/Akt pathway in HepG2 cells[2].
? Chicoric acid (100 μM) has no effects on HepG2 cell viability[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chicoric acid Related Antibodies

Cell Viability Assay[1]

Cell Line: 3T3-L1 preadipocytes
Concentration: 10-200 μM
Incubation Time: 24, 48, and 72 hours
Result: Had no effect on the viability of 3T3-L1 preadipocytes with 10-50 μM for 24 h, but significantly decreased cell viability with 100 μM and 200 μM.

Apoptosis Analysis[1]

Cell Line: 3T3-L1 preadipocytes
Concentration: 100 μM
Incubation Time: 48 hours
Result: Demonstrated typical characteristics of apoptosis such as cell shrinkage, chromatin condensation, and the increased permeability of cell membranes after DAPI and AO/EB staining.

Western Blot Analysis[1]

Cell Line: 3T3-L1 preadipocytes
Concentration: 100 μM
Incubation Time: 48 hours
Result: Decreased the protein level of p-Akt in a dose- and time-dependent manner.
The protein level of total Akt was not affected
In Vivo

Chicoric acid (Cichoric acid; 60 mg/kg/day; drinking water for 4 weeks) inhibits pancreas apoptosis and adjusts islet function in diabetic mice, leading to an increase in insulin generation and secretion in C57BL/6J mice with Streptozotocin (STZ; 50 mg/kg; ip; for consecutive 5 days)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice with STZ (50 mg/kg; ip; for consecutive 5 days)[3]
Dosage: 60 mg/kg
Administration: Drinking water; daily; for 4 weeks
Result: Inhibited pancreas apoptosis and adjusted islet function in diabetic mice, leading to an increase in insulin generation and secretion.
Regulated mitochondrial biogenesis, glycogen synthesis, and inhibited inflammation via activating antioxidant responses.
Showed a remarkable increase in body weight starting at week 7.
Molecular Weight

474.37

Formula

C22H18O12
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(O)[C@H](OC(/C=C/C1=CC=C(O)C(O)=C1)=O)[C@@H](OC(/C=C/C2=CC=C(O)C(O)=C2)=O)C(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (210.81 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1081 mL 10.5403 mL 21.0806 mL
5 mM 0.4216 mL 2.1081 mL 4.2161 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.95%

COA (246 KB) LCMS (264 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.1081 mL 10.5403 mL 21.0806 mL 52.7015 mL
5 mM 0.4216 mL 2.1081 mL 4.2161 mL 10.5403 mL
10 mM 0.2108 mL 1.0540 mL 2.1081 mL 5.2701 mL
15 mM 0.1405 mL 0.7027 mL 1.4054 mL 3.5134 mL
20 mM 0.1054 mL 0.5270 mL 1.0540 mL 2.6351 mL
25 mM 0.0843 mL 0.4216 mL 0.8432 mL 2.1081 mL
30 mM 0.0703 mL 0.3513 mL 0.7027 mL 1.7567 mL
40 mM 0.0527 mL 0.2635 mL 0.5270 mL 1.3175 mL
50 mM 0.0422 mL 0.2108 mL 0.4216 mL 1.0540 mL
60 mM 0.0351 mL 0.1757 mL 0.3513 mL 0.8784 mL
80 mM 0.0264 mL 0.1318 mL 0.2635 mL 0.6588 mL
100 mM 0.0211 mL 0.1054 mL 0.2108 mL 0.5270 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Chicoric acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chicoric acid6537-80-0Cichoric acid Dicaffeoyltartaric acidReactive Oxygen SpeciesApoptosisglucose uptakeinsulin resistanceglucosaminePI3K/AktMAPKantidiabeticantioxidantanti-inflammatoryROSmitochondriap-AktInhibitorinhibitorinhibit

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