2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. CHIR 98024

CHIR 98024 (Compound L) is a glycogen synthase kinase 3 (GSK3) inhibitor with an EC50 of 0.2566 μM.

For research use only. We do not sell to patients.

CHIR 98024 Chemical Structure

CHIR 98024 Chemical Structure

CAS No. : 556813-39-9

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1 mg USD 48 In-stock
5 mg USD 120 In-stock
10 mg USD 190 In-stock
25 mg USD 380 In-stock
50 mg USD 620 In-stock
100 mg USD 980 In-stock
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Based on 1 publication(s) in Google Scholar

CHIR 98024 Related Antibodies

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GSK-3 GSK-3α GSK-3β

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Description

CHIR 98024 (Compound L) is a glycogen synthase kinase 3 (GSK3) inhibitor with an EC50 of 0.2566 μM[1].

IC50 & Target

GSK-3

0.2566 μM (EC50)

Molecular Weight

486.31

Formula

C20H17Cl2N9O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NC1=NC(NCCNC2=NC=C(C3=NC=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2)=CC=C1[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (257.04 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0563 mL 10.2815 mL 20.5630 mL
5 mM 0.4113 mL 2.0563 mL 4.1126 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0563 mL 10.2815 mL 20.5630 mL 51.4075 mL
5 mM 0.4113 mL 2.0563 mL 4.1126 mL 10.2815 mL
10 mM 0.2056 mL 1.0282 mL 2.0563 mL 5.1408 mL
15 mM 0.1371 mL 0.6854 mL 1.3709 mL 3.4272 mL
20 mM 0.1028 mL 0.5141 mL 1.0282 mL 2.5704 mL
25 mM 0.0823 mL 0.4113 mL 0.8225 mL 2.0563 mL
30 mM 0.0685 mL 0.3427 mL 0.6854 mL 1.7136 mL
40 mM 0.0514 mL 0.2570 mL 0.5141 mL 1.2852 mL
50 mM 0.0411 mL 0.2056 mL 0.4113 mL 1.0282 mL
60 mM 0.0343 mL 0.1714 mL 0.3427 mL 0.8568 mL
80 mM 0.0257 mL 0.1285 mL 0.2570 mL 0.6426 mL
100 mM 0.0206 mL 0.1028 mL 0.2056 mL 0.5141 mL
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CHIR 98024 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHIR 98024556813-39-9CHIR98024CHIR-98024GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3ischemic strokeInhibitorinhibitorinhibit

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