Cholesterol-d₆

Name: Cholesterol-d 6
Brand: MedChemExpress
SKU: HY-N0322S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0322S1 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Cholesterol-d₆ is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist.

For research use only. We do not sell to patients.

Cholesterol-d<sub>6</sub> Chemical Structure

Cholesterol-d₆ Chemical Structure

CAS No. : 60816-17-3

Size	Price	Stock	Quantity
1 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Cholesterol-d₆:

Cholesterol In-stock
Cholesterol-d₇ Get quote

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cholesterol-d₆ is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins^[1]^[2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist^[3]^[4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

392.69

Formula

C₂₇H₄₀D₆O

CAS No.

60816-17-3

Unlabeled CAS

57-88-5

Appearance

Solid

Color

White to off-white

SMILES

C[C@H](CCCC(C([2H])([2H])[2H])C([2H])([2H])[2H])[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : 20 mg/mL (50.93 mM; Need ultrasonic)

Ethanol : 20 mg/mL (50.93 mM; Need ultrasonic and warming)

DMSO : 1 mg/mL (2.55 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5465 mL	12.7327 mL	25.4654 mL
5 mM	0.5093 mL	2.5465 mL	5.0931 mL
10 mM	0.2547 mL	1.2733 mL	2.5465 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Casaburi I, et al. Cholesterol as an Endogenous ERRα Agonist: A New Perspective to Cancer Treatment. Front Endocrinol (Lausanne). 2018 Sep 11;9:525. [Content Brief]

[3]. Dietschy JM, et al. Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res. 2004 Aug;45(8):1375-97. [Content Brief]

[4]. Fukui K, et al. Effect of Cholesterol Reduction on Receptor Signaling in Neurons. J Biol Chem. 2015 Sep 14. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO / Ethanol / Ethanol	1 mM	2.5465 mL	12.7327 mL	25.4654 mL	63.6634 mL
Ethanol / Ethanol	5 mM	0.5093 mL	2.5465 mL	5.0931 mL	12.7327 mL
	10 mM	0.2547 mL	1.2733 mL	2.5465 mL	6.3663 mL
	15 mM	0.1698 mL	0.8488 mL	1.6977 mL	4.2442 mL
	20 mM	0.1273 mL	0.6366 mL	1.2733 mL	3.1832 mL
	25 mM	0.1019 mL	0.5093 mL	1.0186 mL	2.5465 mL
	30 mM	0.0849 mL	0.4244 mL	0.8488 mL	2.1221 mL
	40 mM	0.0637 mL	0.3183 mL	0.6366 mL	1.5916 mL
	50 mM	0.0509 mL	0.2547 mL	0.5093 mL	1.2733 mL