Cholesterol-d₇

Name: Cholesterol-d 7
Brand: MedChemExpress
SKU: HY-N0322S
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0322S Purity: 98.29%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Cholesterol-d₇ is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist.

For research use only. We do not sell to patients.

Cholesterol-d<sub>7</sub> Chemical Structure

Cholesterol-d₇ Chemical Structure

CAS No. : 83199-47-7

Size	Price	Stock	Quantity
1 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 210	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Cholesterol-d₇:

Cholesterol In-stock
Cholesterol-d₆ Get quote

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•Related Small Molecules:

•Related Proteins:

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms

Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cholesterol-d₇ is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins^[1]^[2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist^[3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

393.70

Formula

C₂₇H₃₉D₇O

CAS No.

83199-47-7

Unlabeled CAS

57-88-5

Appearance

Solid

Color

White to off-white

SMILES

C[C@@H]([C@]1(CC[C@]2([C@@]3(CC=C4C[C@H](CC[C@@]4([C@]3(CC[C@@]21C)[H])C)O)[H])[H])[H])CCCC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : 20 mg/mL (50.80 mM; Need ultrasonic)

Ethanol : 20 mg/mL (50.80 mM; Need ultrasonic and warming)

DMSO : 1 mg/mL (2.54 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5400 mL	12.7000 mL	25.4001 mL
5 mM	0.5080 mL	2.5400 mL	5.0800 mL
10 mM	0.2540 mL	1.2700 mL	2.5400 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.29%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (249 KB) HNMR (971 KB) RP-HPLC (369 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Casaburi I, et al. Cholesterol as an Endogenous ERRα Agonist: A New Perspective to Cancer Treatment. Front Endocrinol (Lausanne). 2018 Sep 11;9:525. [Content Brief]

[3]. Dietschy JM, et al. Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res. 2004 Aug;45(8):1375-97. [Content Brief]

[4]. Fukui K, et al. Effect of Cholesterol Reduction on Receptor Signaling in Neurons. J Biol Chem. 2015 Sep 14. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO / Ethanol / Ethanol	1 mM	2.5400 mL	12.7000 mL	25.4001 mL	63.5001 mL
Ethanol / Ethanol	5 mM	0.5080 mL	2.5400 mL	5.0800 mL	12.7000 mL
	10 mM	0.2540 mL	1.2700 mL	2.5400 mL	6.3500 mL
	15 mM	0.1693 mL	0.8467 mL	1.6933 mL	4.2333 mL
	20 mM	0.1270 mL	0.6350 mL	1.2700 mL	3.1750 mL
	25 mM	0.1016 mL	0.5080 mL	1.0160 mL	2.5400 mL
	30 mM	0.0847 mL	0.4233 mL	0.8467 mL	2.1167 mL
	40 mM	0.0635 mL	0.3175 mL	0.6350 mL	1.5875 mL
	50 mM	0.0508 mL	0.2540 mL	0.5080 mL	1.2700 mL