CL 316243 free acid

Name: CL 316243 free acid
Brand: MedChemExpress
SKU: HY-116771
Rating: 5.0 (10 reviews)

Cat. No.: HY-116771 Purity: 99.37%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CL316243 free acid is a highly potent selective β3-adrenoceptor agonist with a EC₅₀ of 3 nM, but is an extremely poor to β1/2- receptors. CL316243 free acid is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 free acid has the potential for the treatment obesity, diabetes and urge urinary incontinence.

For research use only. We do not sell to patients.

CL 316243 free acid Chemical Structure

CAS No. : 183720-02-7

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 252	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 500	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 10 publication(s) in Google Scholar

Other Forms of CL 316243 free acid:

CL 316243 Get quote

9 Publications Citing Use of MCE CL 316243 free acid

: CL 316243 free acid purchased from MedChemExpress. Usage Cited in: Food Res Int. 2022: 112198.; CL316243 increases p-AMPKα/AMPKα ratio and UCP1 protein expression in LLE-treated cells.

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

β3 adrenoceptor

In Vitro

CL 316243 free acid displays binding affinities with IC₅₀ values of 0.6 μM and 1 μM for rat heart and rat soleus muscle respectively^[1].
CL 316243 free acid inhibits spontaneously contracting, isolated rat detrusor strips in a concentration dependent manner with a mean concentration inhibiting 50% of maximal response of 2.65 nM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CL316243 free acid (subcutaneously injection; 0.1 mg/kg/day; once a day; 1 weeks) elevates the mRNA and protein expression levels of UCP1 in BAT, irrespective of diet^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6J mice fed with high-fat diets (HFD; 45%-kcal fat) or a control diet (ND; 10%-kcal fat) for 14 weeks^[2]
Dosage:	0.1 mg/kg/day
Administration:	S.c.; once a day; 1 weeks
Result:	Exhibited a premium effect of obesity in mice.

Molecular Weight

421.83

Formula

C₂₀H₂₀ClNO₇

CAS No.

183720-02-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1(C(O)=O)OC2=CC=C(C[C@H](NC[C@@H](C3=CC=CC(Cl)=C3)O)C)C=C2O1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (237.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3706 mL	11.8531 mL	23.7062 mL
5 mM	0.4741 mL	2.3706 mL	4.7412 mL
10 mM	0.2371 mL	1.1853 mL	2.3706 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.37%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (247 KB) HNMR (216 KB) RP-HPLC (118 KB) LCMS (142 KB)

Handling Instructions (2659 KB)

References

[1]. Bloom JD, et al. Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.J Med Chem. 1992 Aug 7;35(16):3081-4. [Content Brief]

[2]. Shin W, et al. Impaired adrenergic agonist-dependent beige adipocyte induction in obese mice.J Vet Med Sci. 2019 Jun 6;81(6):799-807.

[3]. Woods M, et al. Efficacy of the beta3-adrenergic receptor agonist CL-316243 on experimental bladder hyperreflexia and detrusor instability in the rat. J Urol. 2001 Sep;166(3):1142-7.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3706 mL	11.8531 mL	23.7062 mL	59.2656 mL
	5 mM	0.4741 mL	2.3706 mL	4.7412 mL	11.8531 mL
	10 mM	0.2371 mL	1.1853 mL	2.3706 mL	5.9266 mL
	15 mM	0.1580 mL	0.7902 mL	1.5804 mL	3.9510 mL
	20 mM	0.1185 mL	0.5927 mL	1.1853 mL	2.9633 mL
	25 mM	0.0948 mL	0.4741 mL	0.9482 mL	2.3706 mL
	30 mM	0.0790 mL	0.3951 mL	0.7902 mL	1.9755 mL
	40 mM	0.0593 mL	0.2963 mL	0.5927 mL	1.4816 mL
	50 mM	0.0474 mL	0.2371 mL	0.4741 mL	1.1853 mL
	60 mM	0.0395 mL	0.1976 mL	0.3951 mL	0.9878 mL
	80 mM	0.0296 mL	0.1482 mL	0.2963 mL	0.7408 mL
	100 mM	0.0237 mL	0.1185 mL	0.2371 mL	0.5927 mL