2. Anti-infection
  3. Bacterial Antibiotic Parasite
  4. Clindamycin phosphate

Clindamycin phosphate  (Synonyms: Clindamycin 2-phosphate; U-28508)

Cat. No.: HY-B1064 Purity: ≥98.0%
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Clindamycin phosphate (Clindamycin 2-phosphate) is a broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin phosphate is the proagent of Clindamycin (HY-B1455) with no antimicrobial activity in vitro but can be rapidly converted in vivo to the active parent agent, Clindamycin, by phosphatase ester hydrolysis. Clindamycin phosphate can be used for researching acne and bacterial vaginosis.Clindamycin phosphate has no cytotoxicity。 Combined with platelet rich fibrin (PRF), PRF-Clindamycin phosphate enhances antimicrobial properties.

For research use only. We do not sell to patients.

Clindamycin phosphate Chemical Structure

Clindamycin phosphate Chemical Structure

CAS No. : 24729-96-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 66 In-stock
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10 mM * 1 mL in Water USD 66 In-stock
Solid
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Based on 3 publication(s) in Google Scholar

Other Forms of Clindamycin phosphate:

Clindamycin phosphate Related Antibodies

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Description

Clindamycin phosphate (Clindamycin 2-phosphate) is a broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin phosphate is the proagent of Clindamycin (HY-B1455) with no antimicrobial activity in vitro but can be rapidly converted in vivo to the active parent agent, Clindamycin, by phosphatase ester hydrolysis. Clindamycin phosphate can be used for researching acne and bacterial vaginosis[1][2][3].Clindamycin phosphate has no cytotoxicity。 Combined with platelet rich fibrin (PRF), PRF-Clindamycin phosphate enhances antimicrobial properties[4].

IC50 & Target

Antibiotic, Bacterial[1][3]
In Vitro

Clindamycin phosphate (10 mg/ml; 24,48 h) shows no significant cytotoxicity in 3T3 mouse fibroblasts[4].
Clindamycin phosphate has MIC values ranging from 125-250 μg/mL for the four Gram-positive bacteria (S. aureus; S. epidermidis; S. aureus; S. epidermidis) and 52.1-62.5 μg/mL for PRF _ CLP[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clindamycin phosphate Related Antibodies

Cell Cytotoxicity Assay[4]

Cell Line: 3T3 mouse fibroblasts
Concentration: 10 mg/mL PRF_Clindamycin phosphat:0.01-1 mg/mL
Incubation Time: 24, 48 h
Result: Showed no significant cytotoxicity. At 24 and 48 hours, both Clindamycin phosphat and PRF_Clindamycin phosphat samples maintained cell viability above 70%. PRF_Clindamycin phosphat did not show significant differences in cell viability between different dilutions .
Clinical Trial
Molecular Weight

504.96

Formula

C18H34ClN2O8PS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCC[C@H]1CN(C)[C@H](C(N[C@@]([H])([C@@]2([H])O[C@H](SC)[C@H](OP(O)(O)=O)[C@@H](O)[C@H]2O)[C@@H](Cl)C)=O)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (198.04 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9804 mL 9.9018 mL 19.8035 mL
5 mM 0.3961 mL 1.9804 mL 3.9607 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (99.02 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (253 KB) HNMR (271 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.9804 mL 9.9018 mL 19.8035 mL 49.5089 mL
5 mM 0.3961 mL 1.9804 mL 3.9607 mL 9.9018 mL
10 mM 0.1980 mL 0.9902 mL 1.9804 mL 4.9509 mL
15 mM 0.1320 mL 0.6601 mL 1.3202 mL 3.3006 mL
20 mM 0.0990 mL 0.4951 mL 0.9902 mL 2.4754 mL
25 mM 0.0792 mL 0.3961 mL 0.7921 mL 1.9804 mL
30 mM 0.0660 mL 0.3301 mL 0.6601 mL 1.6503 mL
40 mM 0.0495 mL 0.2475 mL 0.4951 mL 1.2377 mL
50 mM 0.0396 mL 0.1980 mL 0.3961 mL 0.9902 mL
60 mM 0.0330 mL 0.1650 mL 0.3301 mL 0.8251 mL
80 mM 0.0248 mL 0.1238 mL 0.2475 mL 0.6189 mL
100 mM 0.0198 mL 0.0990 mL 0.1980 mL 0.4951 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Clindamycin phosphate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clindamycin24729-96-2Clindamycin 2-phosphate U-28508U28508U 28508U-28508BacterialAntibioticParasitebroad-spectrumbacteriostaticlincosamideprodrugphosphatase ester hydrolysisacnebacterial vaginosisInhibitorinhibitorinhibit

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