Corticosterone-d₈

Name: Corticosterone-d 8
Brand: MedChemExpress
SKU: HY-B1618S
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1618S Purity: 99.91%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Corticosterone-d₈ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

For research use only. We do not sell to patients.

Corticosterone-d<sub>8</sub> Chemical Structure

Corticosterone-d₈ Chemical Structure

CAS No. : 1271728-07-4

Size	Price	Stock	Quantity
1 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Corticosterone-d₈:

Corticosterone In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Corticosterone-d₈ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

354.51

Formula

C₂₁H₂₂D₈O₄

CAS No.

1271728-07-4

Unlabeled CAS

50-22-6

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@]3([H])[C@](CC([2H])([2H])C1=C([2H])C(C([2H])([2H])C2)=O)([H])[C@@]4([H])[C@](C[C@@H]3O)([C@@](CC4)([2H])C(C([2H])([2H])O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (282.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 100 mg/mL (282.08 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 14.29 mg/mL (40.31 mM; Need ultrasonic)

H₂O : 0.67 mg/mL (1.89 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8208 mL	14.1040 mL	28.2079 mL
5 mM	0.5642 mL	2.8208 mL	5.6416 mL
10 mM	0.2821 mL	1.4104 mL	2.8208 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.91%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (256 KB) HNMR (268 KB) LCMS (88 KB) Elemental Analysis Report (114 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Gasser PJ, et al. Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organiccation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. J Neurosci. 2006 Aug 23;26(34):8758-8766. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O / Ethanol / Ethanol / DMSO / DMSO	1 mM	2.8208 mL	14.1040 mL	28.2079 mL	70.5199 mL
Ethanol / Ethanol / DMSO / DMSO	5 mM	0.5642 mL	2.8208 mL	5.6416 mL	14.1040 mL
	10 mM	0.2821 mL	1.4104 mL	2.8208 mL	7.0520 mL
	15 mM	0.1881 mL	0.9403 mL	1.8805 mL	4.7013 mL
	20 mM	0.1410 mL	0.7052 mL	1.4104 mL	3.5260 mL
	25 mM	0.1128 mL	0.5642 mL	1.1283 mL	2.8208 mL
	30 mM	0.0940 mL	0.4701 mL	0.9403 mL	2.3507 mL
	40 mM	0.0705 mL	0.3526 mL	0.7052 mL	1.7630 mL
DMSO / DMSO	50 mM	0.0564 mL	0.2821 mL	0.5642 mL	1.4104 mL
	60 mM	0.0470 mL	0.2351 mL	0.4701 mL	1.1753 mL
	80 mM	0.0353 mL	0.1763 mL	0.3526 mL	0.8815 mL
	100 mM	0.0282 mL	0.1410 mL	0.2821 mL	0.7052 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.