CRBN ligand-9

Cat. No.: HY-W342590 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CRBN ligand-9 (Compound 4d) is a CRBN ligand (K_i: 8.9 μM). CRBN ligand-9 can be used for synthesis of PROTACs.

For research use only. We do not sell to patients.

CRBN ligand-9 Chemical Structure

CAS No. : 55003-81-1

Size	Price	Stock
100 mg	USD 30	Ask For Quote & Lead Time
250 mg	USD 45	Ask For Quote & Lead Time
1 g	USD 90	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

Biological Activity
Purity & Documentation
References
Customer Review

Description

CRBN ligand-9 (Compound 4d) is a CRBN ligand (K_i: 8.9 μM). CRBN ligand-9 can be used for synthesis of PROTACs^[1]^[2].

IC₅₀ & Target

Cereblon

Molecular Weight

303.23

Formula

C₁₃H₉N₃O₆

CAS No.

55003-81-1

Appearance

Solid

Color

Off-white to gray

SMILES

O=C1NC(CCC1N2C(C3=CC=C(C=C3C2=O)[N+](=O)[O-])=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (329.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2978 mL	16.4891 mL	32.9783 mL
5 mM	0.6596 mL	3.2978 mL	6.5957 mL
10 mM	0.3298 mL	1.6489 mL	3.2978 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (249 KB) HNMR (132 KB) LCMS (92 KB)

Handling Instructions (2659 KB)

References

[1]. Heim C,et al. De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. J Med Chem. 2019 Jul 25;62(14):6615-6629. [Content Brief]

[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2978 mL	16.4891 mL	32.9783 mL	82.4457 mL
	5 mM	0.6596 mL	3.2978 mL	6.5957 mL	16.4891 mL
	10 mM	0.3298 mL	1.6489 mL	3.2978 mL	8.2446 mL
	15 mM	0.2199 mL	1.0993 mL	2.1986 mL	5.4964 mL
	20 mM	0.1649 mL	0.8245 mL	1.6489 mL	4.1223 mL
	25 mM	0.1319 mL	0.6596 mL	1.3191 mL	3.2978 mL
	30 mM	0.1099 mL	0.5496 mL	1.0993 mL	2.7482 mL
	40 mM	0.0824 mL	0.4122 mL	0.8245 mL	2.0611 mL
	50 mM	0.0660 mL	0.3298 mL	0.6596 mL	1.6489 mL
	60 mM	0.0550 mL	0.2748 mL	0.5496 mL	1.3741 mL
	80 mM	0.0412 mL	0.2061 mL	0.4122 mL	1.0306 mL
	100 mM	0.0330 mL	0.1649 mL	0.3298 mL	0.8245 mL

CRBN ligand-9 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-955003-81-1CRBN ligand9CRBN ligand 9Ligands for E3 LigaseE3 ligase-recruiting MoietyCRBN ligandPROTACsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks