1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. CRT0063465

CRT0063465 is a Ligand of HumanPGK1andStress Sensor DJ1, with theKdof 24 μM ofPGK1. CRT0063465 modulates the shelterin complex composition and telomere Length.

For research use only. We do not sell to patients.

CRT0063465 Chemical Structure

CRT0063465 Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Description

CRT0063465 is a Ligand of HumanPGK1andStress Sensor DJ1, with theKdof 24 μM ofPGK1. CRT0063465 modulates the shelterin complex composition and telomere Length[1].

In Vivo

CRT0063465 (10, 100 nM, up to 84 days) blocks hypoglycemic telomere shortening in TCT116 cells[1].
CRT0063465 (10 nM, 1 week) modulates the composition of shelterin complexes in unstressed HCT116 cells[1].
CRT0063465 (100 nM, up to 100 h) has protective effect against Bleomycin (HY-17565)-induced cytotoxicity in A2780 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

374.23

Formula

C17H16BrN3O2

Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=C(CCC(O)=O)C(C)=NC2=CC(C3=CC=C(Br)C=C3)=NN12

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
CRT0063465
Cat. No.:
HY-153917
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