2. Protein Tyrosine Kinase/RTK
  3. c-Fms
  4. CSF1R-IN-12

CSF1R-IN-12 is a potent inhibitor of CSF1R. Colony stimulating factor 1 (CSF-1, also known as macrophage colony stimulating factor, M-CSF) is an important growth factor that controls bone marrow progenitor cells, monocytes, macrophages, and giants. CSF1R-IN-12 has the potential for the research of cancer diseases (extracted from patent WO2019134661A1, compound 1).

For research use only. We do not sell to patients.

CSF1R-IN-12 Chemical Structure

CSF1R-IN-12 Chemical Structure

CAS No. : 2361556-35-4

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5 mg USD 150 In-stock
10 mg USD 240 In-stock
25 mg USD 480 In-stock
50 mg USD 780 In-stock
100 mg USD 1250 In-stock
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Based on 1 publication(s) in Google Scholar

CSF1R-IN-12 Related Antibodies

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Description

CSF1R-IN-12 is a potent inhibitor of CSF1R. Colony stimulating factor 1 (CSF-1, also known as macrophage colony stimulating factor, M-CSF) is an important growth factor that controls bone marrow progenitor cells, monocytes, macrophages, and giants. CSF1R-IN-12 has the potential for the research of cancer diseases (extracted from patent WO2019134661A1, compound 1)[1].

Molecular Weight

398.38

Formula

C21H17F3N4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC(NCC2=CN=C(C=C2)C(F)(F)F)=NC=C1C3=CC=CC4=C3CNC4=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (251.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5102 mL 12.5508 mL 25.1017 mL
5 mM 0.5020 mL 2.5102 mL 5.0203 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5102 mL 12.5508 mL 25.1017 mL 62.7542 mL
5 mM 0.5020 mL 2.5102 mL 5.0203 mL 12.5508 mL
10 mM 0.2510 mL 1.2551 mL 2.5102 mL 6.2754 mL
15 mM 0.1673 mL 0.8367 mL 1.6734 mL 4.1836 mL
20 mM 0.1255 mL 0.6275 mL 1.2551 mL 3.1377 mL
25 mM 0.1004 mL 0.5020 mL 1.0041 mL 2.5102 mL
30 mM 0.0837 mL 0.4184 mL 0.8367 mL 2.0918 mL
40 mM 0.0628 mL 0.3138 mL 0.6275 mL 1.5689 mL
50 mM 0.0502 mL 0.2510 mL 0.5020 mL 1.2551 mL
60 mM 0.0418 mL 0.2092 mL 0.4184 mL 1.0459 mL
80 mM 0.0314 mL 0.1569 mL 0.3138 mL 0.7844 mL
100 mM 0.0251 mL 0.1255 mL 0.2510 mL 0.6275 mL
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CSF1R-IN-12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CSF1R-IN-122361556-35-4c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1Rgrowth factorcancerInhibitorinhibitorinhibit

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