2. Metabolic Enzyme/Protease
  3. MMP
  4. CTTHWGFTLC, CYCLIC TFA

CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC50 value for MMP-9 is ~8 μM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CTTHWGFTLC, CYCLIC TFA Chemical Structure

CTTHWGFTLC, CYCLIC TFA Chemical Structure

Size Price Stock Quantity
5 mg USD 340 In-stock
10 mg USD 630 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of CTTHWGFTLC, CYCLIC TFA:

CTTHWGFTLC, CYCLIC TFA Related Antibodies

Top Publications Citing Use of Products

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC50 value for MMP-9 is ~8 μM[1].

IC50 & Target

MMP-2

 

MMP-9

 

In Vitro

CTTHWGFTLC, CYCLIC TFA inhibits endothelial and tumor cell migration in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CTTHWGFTLC, CYCLIC TFA Related Antibodies
In Vivo

CTTHWGFTLC, CYCLIC TFA inhibits tumor progression in vivo, in mouse models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1280.35

Formula

C54H72F3N13O16S2
Appearance

Solid

Color

White to off-white

Sequence

Cys-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys (Disulfide Bridge: Cys1-Cys10)
Sequence Shortening

CTTHWGFTLC (Disulfide Bridge: Cys1-Cys10)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (39.05 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7810 mL 3.9052 mL 7.8104 mL
5 mM 0.1562 mL 0.7810 mL 1.5621 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7810 mL 3.9052 mL 7.8104 mL 19.5259 mL
5 mM 0.1562 mL 0.7810 mL 1.5621 mL 3.9052 mL
10 mM 0.0781 mL 0.3905 mL 0.7810 mL 1.9526 mL
15 mM 0.0521 mL 0.2603 mL 0.5207 mL 1.3017 mL
20 mM 0.0391 mL 0.1953 mL 0.3905 mL 0.9763 mL
25 mM 0.0312 mL 0.1562 mL 0.3124 mL 0.7810 mL
30 mM 0.0260 mL 0.1302 mL 0.2603 mL 0.6509 mL
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CTTHWGFTLC, CYCLIC TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CTTHWGFTLC, CYCLICMMPMatrix metalloproteinasesMMP-2MMP-9tumorangiogenesismetastasisrheumatoidarthritismultiplesclerosisperiodontitisInhibitorinhibitorinhibit

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