2. Metabolic Enzyme/Protease Apoptosis
  3. Stearoyl-CoA Desaturase (SCD) Apoptosis
  4. CVT-11127

CVT-11127  (Synonyms: GS-456332)

Cat. No.: HY-113638 Purity: 99.88%
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CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CVT-11127 Chemical Structure

CVT-11127 Chemical Structure

CAS No. : 1018674-83-3

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1 mg USD 119 In-stock
5 mg USD 250 In-stock
10 mg USD 350 In-stock
25 mg USD 600 In-stock
50 mg USD 900 In-stock
100 mg USD 1350 In-stock
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Based on 1 publication(s) in Google Scholar

CVT-11127 Related Antibodies

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Description

CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer[1].

IC50 & Target

SCD[1]
In Vitro

CVT-11127 (1 µM, 48 h) shows antiproliferation activity in H460 cells[1].
CVT-11127 (1 µM, 48 h) decreases the the population of cells in S-phase by 75%[1].
CVT-11127 (1 µM, 48 h) induces apoposis in H460 cells[1].
CVT-11127 (1, 2 µM) inhibitors the SCD (stearoylCoA desaturase) activity in H460 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CVT-11127 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: H460 cells
Concentration: 1 µM
Incubation Time: 48 h
Result: Showed antiproliferation activity.

Cell Cycle Analysis[1]

Cell Line: H460 cells
Concentration: 1 µM
Incubation Time: 48 h
Result: Decreased the the population of cells in S-phase by 75%.

Apoptosis Analysis[1]

Cell Line: H460 cells
Concentration: 1 µM
Incubation Time: 24 h
Result: Induced apoposis H460 cells.
Molecular Weight

512.39

Formula

C25H23Cl2N5O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (48.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9516 mL 9.7582 mL 19.5164 mL
5 mM 0.3903 mL 1.9516 mL 3.9033 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9516 mL 9.7582 mL 19.5164 mL 48.7910 mL
5 mM 0.3903 mL 1.9516 mL 3.9033 mL 9.7582 mL
10 mM 0.1952 mL 0.9758 mL 1.9516 mL 4.8791 mL
15 mM 0.1301 mL 0.6505 mL 1.3011 mL 3.2527 mL
20 mM 0.0976 mL 0.4879 mL 0.9758 mL 2.4395 mL
25 mM 0.0781 mL 0.3903 mL 0.7807 mL 1.9516 mL
30 mM 0.0651 mL 0.3253 mL 0.6505 mL 1.6264 mL
40 mM 0.0488 mL 0.2440 mL 0.4879 mL 1.2198 mL
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CVT-11127 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CVT-111271018674-83-3GS-456332CVT11127CVT 11127GS456332GS 456332Stearoyl-CoA Desaturase (SCD)ApoptosisH460 cellsapoposisS-phaselung cancerantiproliferationmonounsaturated fatty acids (MUFA)Inhibitorinhibitorinhibit

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