2. GPCR/G Protein Vitamin D Related/Nuclear Receptor Neuronal Signaling
  3. 5-HT Receptor Androgen Receptor
  4. CYB210010

CYB210010 is an orally bioavailable, long-acting serotonin 5-HT2 receptor agonist that selectively targets 5-HT2A and 5-HT2C receptors (EC50: 4.1 n, 7.3 nM). CYB210010 can enter the central nervous system, cause a head twitch response (HTR), and is not prone to behavioral tolerance during chronic administration.

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CYB210010 Chemical Structure

CYB210010 Chemical Structure

CAS No. : 2762568-47-6

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Description

CYB210010 is an orally bioavailable, long-acting serotonin 5-HT2 receptor agonist that selectively targets 5-HT2A and 5-HT2C receptors (EC50: 4.1 n, 7.3 nM). CYB210010 can enter the central nervous system, cause a head twitch response (HTR), and is not prone to behavioral tolerance during chronic administration[1].

IC50 & Target[1]

5-HT1A Receptor

32 nM (Ki)

5-HT1B Receptor

949 nM (Ki)

5-HT6 Receptor

1301 nM (Ki)

5-HT7 Receptor

4918 nM (Ki)

5-HT2A Receptor

4.1 nM (EC50)

5-HT2C Receptor

7.3 nM (EC50)

5-HT2B Receptor

88 nM (EC50)

In Vivo

CYB210010 has certain oral bioavailability and can smoothly enter the central nervous system, bind to 5-HT2A receptors in the frontal cortex, and increase the expression of neuroplasticity-related genes in the frontal cortex[1].
CYB210010 (0.1-3 mg/kg; sc; single dose) causes a head twitch response (HTR) in mouse, and can be administered subchronically at threshold doses without developing behavioral tolerance[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice[1]
Dosage: 0.1, 0.3, 1, 3, mg/kg
Administration: sc; sigle dose
Result: Elicited maximum HTRs at ∼15 min postadministration which terminated after 220 min (significant from vehicle from 5-160 min).
Molecular Weight

317.76

Formula

C11H15ClF3NO2S
CAS No.
SMILES

COC1=C(CCN)C=C(OC)C(SC(F)(F)F)=C1.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CYB210010 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYB2100102762568-47-6CYB 210010CYB-2100105-HT ReceptorAndrogen ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorOral active5-HThead twitch responseHTRInhibitorinhibitorinhibit

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