NAV 26

Cat. No.: HY-118048 Purity: 99.79%: FAQs
Data Sheet SDS COA Handling Instructions

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NAV 26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC₅₀ of 0.37 μM. NAV 26 can be used for pain research.

For research use only. We do not sell to patients.

NAV 26 Chemical Structure

CAS No. : 1198160-14-3

Size	Price	Stock	Quantity
5 mg	USD 356	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 570	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8

Biological Activity
Purity & Documentation
References
Customer Review

Description

NAV 26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC₅₀ of 0.37 μM. NAV 26 can be used for pain research^[1].

IC₅₀ & Target^[1]

Na_v1.7

0.37 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	IC₅₀	> 30 μM Compound: 26B, enantiomer 2	Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay	[PMID: 22770500]
CHO-K1	IC₅₀	> 33 μM Compound: 26	Binding affinity to human ERG expressed in CHOK1 cells by IonWorks HT assay Binding affinity to human ERG expressed in CHOK1 cells by IonWorks HT assay	[PMID: 22770500]
CHO-K1	IC₅₀	> 33 μM Compound: 26A, enantiomer 1	Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay	[PMID: 22770500]
CHO-K1	IC₅₀	> 33 μM Compound: 26	Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay	[PMID: 22770500]
CHO-K1	IC₅₀	> 33 μM Compound: 26B, enantiomer 2	Inhibition of human NaV1.2 alpha subunit expressed in CHOK1 cells at -65 mV holding potential by patch clamp electrophysiological assay Inhibition of human NaV1.2 alpha subunit expressed in CHOK1 cells at -65 mV holding potential by patch clamp electrophysiological assay	[PMID: 22770500]
CHO-K1	IC₅₀	> 33 μM Compound: 26B, enantiomer 2	Binding affinity to human ERG expressed in CHOK1 cells by IonWorks HT assay Binding affinity to human ERG expressed in CHOK1 cells by IonWorks HT assay	[PMID: 22770500]
HEK293	IC₅₀	> 33 μM Compound: 26B, enantiomer 2	Inhibition of human NaV1.7 F1737A mutant expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay Inhibition of human NaV1.7 F1737A mutant expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay	[PMID: 22770500]
HEK293	IC₅₀	0.37 μM Compound: 26	Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay	[PMID: 22770500]
HEK293	IC₅₀	0.41 μM Compound: 26B, enantiomer 2	Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay	[PMID: 22770500]
HEK293	IC₅₀	1.6 μM Compound: 26B, enantiomer 2	Inhibition of recombinant rat NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay Inhibition of recombinant rat NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay	[PMID: 22770500]
HEK293	IC₅₀	2 μM Compound: 26A, enantiomer 1	Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay	[PMID: 22770500]
HEK293	IC₅₀	3.8 μM Compound: 26B, enantiomer 2	Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -90 mV holding potential by patch clamp electrophysiological assay Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -90 mV holding potential by patch clamp electrophysiological assay	[PMID: 22770500]

Molecular Weight

434.41

Formula

C₂₂H₂₁F₃N₂O₄

CAS No.

1198160-14-3

Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=CC=CC=C2C(N1C3CCOCC3)C(NCC4=CC=C(C=C4)OC(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (287.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3020 mL	11.5099 mL	23.0197 mL
5 mM	0.4604 mL	2.3020 mL	4.6039 mL
10 mM	0.2302 mL	1.1510 mL	2.3020 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.79%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (253 KB) HNMR (263 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Istvan Macsari, et al. 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J Med Chem. 2012 Aug 9;55(15):6866-80. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3020 mL	11.5099 mL	23.0197 mL	57.5493 mL
	5 mM	0.4604 mL	2.3020 mL	4.6039 mL	11.5099 mL
	10 mM	0.2302 mL	1.1510 mL	2.3020 mL	5.7549 mL
	15 mM	0.1535 mL	0.7673 mL	1.5346 mL	3.8366 mL
	20 mM	0.1151 mL	0.5755 mL	1.1510 mL	2.8775 mL
	25 mM	0.0921 mL	0.4604 mL	0.9208 mL	2.3020 mL
	30 mM	0.0767 mL	0.3837 mL	0.7673 mL	1.9183 mL
	40 mM	0.0575 mL	0.2877 mL	0.5755 mL	1.4387 mL
	50 mM	0.0460 mL	0.2302 mL	0.4604 mL	1.1510 mL
	60 mM	0.0384 mL	0.1918 mL	0.3837 mL	0.9592 mL
	80 mM	0.0288 mL	0.1439 mL	0.2877 mL	0.7194 mL
	100 mM	0.0230 mL	0.1151 mL	0.2302 mL	0.5755 mL

NAV 26 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NAV 261198160-14-3NAV26NAV-26Sodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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NAV 26

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NAV 26 Related Antibodies

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References

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Complete Stock Solution Preparation Table

NAV 26 Related Classifications

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