2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Cyclanoline chloride

Cyclanoline (chloride) shows cholinesterase inhibitory activity.

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Cyclanoline chloride Chemical Structure

Cyclanoline chloride Chemical Structure

CAS No. : 17472-50-3

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Description

Cyclanoline (chloride) shows cholinesterase inhibitory activity[1].

Molecular Weight

377.86

Formula

C20H24ClNO4
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

C[N@@+]12CCC3=CC(OC)=C(O)C=C3[C@]1([H])CC4=CC=C(OC)C(O)=C4C2.[Cl-]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (264.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6465 mL 13.2324 mL 26.4648 mL
5 mM 0.5293 mL 2.6465 mL 5.2930 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 96.27%

COA (250 KB) RP-HPLC (228 KB) LCMS (257 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6465 mL 13.2324 mL 26.4648 mL 66.1621 mL
5 mM 0.5293 mL 2.6465 mL 5.2930 mL 13.2324 mL
10 mM 0.2646 mL 1.3232 mL 2.6465 mL 6.6162 mL
15 mM 0.1764 mL 0.8822 mL 1.7643 mL 4.4108 mL
20 mM 0.1323 mL 0.6616 mL 1.3232 mL 3.3081 mL
25 mM 0.1059 mL 0.5293 mL 1.0586 mL 2.6465 mL
30 mM 0.0882 mL 0.4411 mL 0.8822 mL 2.2054 mL
40 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.6541 mL
50 mM 0.0529 mL 0.2646 mL 0.5293 mL 1.3232 mL
60 mM 0.0441 mL 0.2205 mL 0.4411 mL 1.1027 mL
80 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.8270 mL
100 mM 0.0265 mL 0.1323 mL 0.2646 mL 0.6616 mL
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Cyclanoline chloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclanoline17472-50-3Cholinesterase (ChE)Inhibitorinhibitorinhibit

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