Cyclo(glycyl-L-leucyl) (Synonyms: Cyclo(leu-gly))

Cat. No.: HY-W152604: FAQs
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Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA.html" class="link-product" target="_blank">L-DOPA (HY-N0304)-induced dyskinesias.

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Cyclo(glycyl-L-leucyl) Chemical Structure

CAS No. : 5845-67-0

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Description

IC₅₀ & Target^[1]

Dopamine Receptor

In Vivo

Cyclo(glycyl-L-leucyl) (8 mg/kg; s.c.) given 24h after apomorphine (APO) attenuates the DA receptor supersensitivity caused by acute high dose APO (5 mg/kg; s.c.)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Swiss-Webster mice, 20-25g^[1]
Dosage:	8 mg/kg
Administration:	SC; single dose given 24h after apomorphine (APO)
Result:	Attenuated the DA receptor supersensitivity caused by acute high dose APO (5 mg/kg; s.c.).

Molecular Weight

170.21

Formula

C₈H₁₄N₂O₂

CAS No.

5845-67-0

SMILES

CC(C[C@H]1C(NCC(N1)=O)=O)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. J Z Fields, et al. The effects of cyclo(leucyl-glycyl) on nigrostriatal dopaminergic supersensitivity--inhibition of apomorphine-induced climbing. Neuropeptides. 1990 Aug;16(4):207-11. [Content Brief]

[2]. H N Bhargava, et al. Cyclo (leucylglycine) inhibits the development of morphine induced analgesic tolerance and dopamine receptor supersensitivity in rats. Life Sci. 1980 Jul 14;27(2):117-23. [Content Brief]

Cyclo(glycyl-L-leucyl) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(glycyl-L-leucyl)5845-67-0Cyclo(leu-gly)Dopamine Receptorneuropeptidedopaminergic supersensitivityMorphinepaintardiveL-DOPA dyskinesiasInhibitorinhibitorinhibit

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