2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Cyclo(glycyl-L-leucyl)

Cyclo(glycyl-L-leucyl)  (Synonyms: Cyclo(leu-gly))

Cat. No.: HY-W152604
Data Sheet Handling Instructions Technical Support

Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA.html" class="link-product" target="_blank">L-DOPA (HY-N0304)-induced dyskinesias.

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Cyclo(glycyl-L-leucyl) Chemical Structure

Cyclo(glycyl-L-leucyl) Chemical Structure

CAS No. : 5845-67-0

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  • References

  • Customer Review

Description

Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA.html" class="link-product" target="_blank">L-DOPA (HY-N0304)-induced dyskinesias[1][2].

IC50 & Target[1]

Dopamine Receptor

 

In Vivo

Cyclo(glycyl-L-leucyl) (8 mg/kg; s.c.) given 24h after apomorphine (APO) attenuates the DA receptor supersensitivity caused by acute high dose APO (5 mg/kg; s.c.)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss-Webster mice, 20-25g[1]
Dosage: 8 mg/kg
Administration: SC; single dose given 24h after apomorphine (APO)
Result: Attenuated the DA receptor supersensitivity caused by acute high dose APO (5 mg/kg; s.c.).
Molecular Weight

170.21

Formula

C8H14N2O2
CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
Purity & Documentation
References
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Cyclo(glycyl-L-leucyl) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Cyclo(glycyl-L-leucyl)5845-67-0Cyclo(leu-gly)Dopamine Receptorneuropeptidedopaminergic supersensitivityMorphinepaintardiveL-DOPA dyskinesiasInhibitorinhibitorinhibit

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