Cyclogalegenin (Synonyms: Cyclogalegigenin)

Name: Cyclogalegenin
Brand: MedChemExpress
SKU: HY-N0424
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0424 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Cyclogalegenin (Cyclogalegigenin) is a isoprenoid that can be isolated from Astragalus galegiformis. Cyclogalegenin is the enantiomer of Cycloastragenol.

For research use only. We do not sell to patients.

Cyclogalegenin Chemical Structure

CAS No. : 84605-18-5

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 28	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 28	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Cyclogalegenin:

Cycloastragenol Get quote

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Description

Cyclogalegenin (Cyclogalegigenin) is a isoprenoid that can be isolated from Astragalus galegiformis. Cyclogalegenin is the enantiomer of Cycloastragenol^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.542 μM Compound: 8	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28482219]
DU-145	IC₅₀	7.258 μM Compound: 8	Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28482219]
HEK293	IC₅₀	127.7 μM Compound: 8	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28482219]
HeLa	IC₅₀	2.198 μM Compound: 8	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28482219]
MCF7	IC₅₀	1.778 μM Compound: 8	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28482219]

Molecular Weight

490.72

Formula

C₃₀H₅₀O₅

CAS No.

84605-18-5

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1CC[C@@]2(C3)[C@]([C@@H](O)C[C@]4([H])[C@@]23CC[C@@]5(C)[C@@]4(C)C[C@H](O)[C@]5([H])[C@@]6(C)O[C@@H](C(C)(C)O)CC6)([H])C1(C)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (203.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0378 mL	10.1891 mL	20.3782 mL
5 mM	0.4076 mL	2.0378 mL	4.0756 mL
10 mM	0.2038 mL	1.0189 mL	2.0378 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (5.09 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.09 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (254 KB) HNMR (284 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Alaniya M D, et al. Triterpene glycosides of Astragalus and of their genins. X. Cyclogalegigenin from Astragalus galegiformis. Chemistry of Natural Compounds. 1983, 19: 314-320.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0378 mL	10.1891 mL	20.3782 mL	50.9455 mL
	5 mM	0.4076 mL	2.0378 mL	4.0756 mL	10.1891 mL
	10 mM	0.2038 mL	1.0189 mL	2.0378 mL	5.0946 mL
	15 mM	0.1359 mL	0.6793 mL	1.3585 mL	3.3964 mL
	20 mM	0.1019 mL	0.5095 mL	1.0189 mL	2.5473 mL
	25 mM	0.0815 mL	0.4076 mL	0.8151 mL	2.0378 mL
	30 mM	0.0679 mL	0.3396 mL	0.6793 mL	1.6982 mL
	40 mM	0.0509 mL	0.2547 mL	0.5095 mL	1.2736 mL
	50 mM	0.0408 mL	0.2038 mL	0.4076 mL	1.0189 mL
	60 mM	0.0340 mL	0.1698 mL	0.3396 mL	0.8491 mL
	80 mM	0.0255 mL	0.1274 mL	0.2547 mL	0.6368 mL
	100 mM	0.0204 mL	0.1019 mL	0.2038 mL	0.5095 mL

Cyclogalegenin Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclogalegenin84605-18-5CyclogalegigeninOthersAstragalus galegiformisCycloastragenolenantiomerInhibitorinhibitorinhibit

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Cyclogalegenin (Synonyms: Cyclogalegigenin)

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Other Forms of Cyclogalegenin:

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Complete Stock Solution Preparation Table

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