2. Cell Cycle/DNA Damage Cytoskeleton Antibody-drug Conjugate/ADC Related
  3. Microtubule/Tubulin Drug-Linker Conjugates for ADC
  4. Cys-mcMMAD

Cys-mcMMAD is a agent-linker conjugate for ADC. MMAD is a potent tubulin inhibitor.

For research use only. We do not sell to patients.

Cys-mcMMAD Chemical Structure

Cys-mcMMAD Chemical Structure

Size Price Stock Quantity
1 mg In-stock
5 mg In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cys-mcMMAD is a agent-linker conjugate for ADC. MMAD is a potent tubulin inhibitor.

IC50 & Target

Auristatin

 

Molecular Weight

1085.42

Formula

C54H84N8O11S2
Appearance

Solid

Color

White to off-white

SMILES

CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C2=NC=CS2)CC3=CC=CC=C3)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(CCCCCN4C(CC(SC[C@@H](C(O)=O)N)C4=O)=O)=O)C)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (184.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9213 mL 4.6065 mL 9.2130 mL
5 mM 0.1843 mL 0.9213 mL 1.8426 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (4.61 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 5 mg/mL (4.61 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 98.77%

Data Sheet (271 KB) SDS (251 KB)

COA (250 KB) HNMR (407 KB) LCMS (106 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9213 mL 4.6065 mL 9.2130 mL 23.0326 mL
5 mM 0.1843 mL 0.9213 mL 1.8426 mL 4.6065 mL
10 mM 0.0921 mL 0.4607 mL 0.9213 mL 2.3033 mL
15 mM 0.0614 mL 0.3071 mL 0.6142 mL 1.5355 mL
20 mM 0.0461 mL 0.2303 mL 0.4607 mL 1.1516 mL
25 mM 0.0369 mL 0.1843 mL 0.3685 mL 0.9213 mL
30 mM 0.0307 mL 0.1536 mL 0.3071 mL 0.7678 mL
40 mM 0.0230 mL 0.1152 mL 0.2303 mL 0.5758 mL
50 mM 0.0184 mL 0.0921 mL 0.1843 mL 0.4607 mL
60 mM 0.0154 mL 0.0768 mL 0.1536 mL 0.3839 mL
80 mM 0.0115 mL 0.0576 mL 0.1152 mL 0.2879 mL
100 mM 0.0092 mL 0.0461 mL 0.0921 mL 0.2303 mL
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Cys-mcMMAD Related Classifications

Keywords:

Cys-mcMMADMicrotubule/TubulinDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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